The effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicity

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.contributor.authorGulec, M
dc.contributor.authorIraz, M
dc.contributor.authorYilmaz, HR
dc.contributor.authorOzyurt, H
dc.contributor.authorTemel, I
dc.date.accessioned2024-08-04T20:15:25Z
dc.date.available2024-08-04T20:15:25Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was carried out to determine if Ginkgo Biloba Extract (GBE or Egb 761) exerts a beneficial effect against cisplatin-induced renal failure in rats. Sprague Dawley rats were divided into four groups. The first group (control) received orally 1 mL/kg/day of 0.9% saline by an oral carrier vehicle on days 1 to 10. The second group was injected with 7 mg/kg cisplatin intraperitoneally (i.p.) on the fourth day, once only. The third group (vit E + cisplatin) was administered 10 mg/kg/day i.p. vit E on 1 to 10 days with one dose of i.p. cisplatin (7 mg/kg) injection on the fourth day. The fourth group (GBE + cisplatin) was given GBE orally at 100 mg/mL/kg started on the first day up to the tenth day with one dose of cisplatin (7 mg/kg) injection on the fourth day. Cisplatin was found to lead a statistically significant increase in plasma BUN and creatinine levels, as well as urine micro total protein (MTP) levels, leading to acute renal failure (ARF) in rats. Renal xanthine oxidase (XO) activities increased in all groups (statistically significant in cisplatin + GBE-treated rats; P < 0.001). Adenosine deaminase (AD) activities were increased in cisplatin-treated rats, and decreased in cisplatin + GBE-treated (P < 0.041) and cisplatin + vit E-treated (P < 0.005) rats, compared to controls. Malondialdehyde (MDA), nitric oxide (NO) levels and myeloperoxidase (MPO) activities were increased in the kidney tissue of cisplatin-treated rats. Vit E improved plasma creatinine and urine MTP levels, together with tissue MDA, NO levels, and MPO activities. But GBE had no statistically significant effect on those parameters. These results indicate that increased XO, AD and MPO activities, as well as MDA and NO levels play a critical role in cisplatin nephrotoxicity. GBE has been shown to protect against cisplatin-induced nephrotoxicity.en_US
dc.identifier.doi10.1191/0748233705th255oa
dc.identifier.endpage130en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue3en_US
dc.identifier.pmid16716042en_US
dc.identifier.scopus2-s2.0-33646346594en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1191/0748233705th255oa
dc.identifier.urihttps://hdl.handle.net/11616/94374
dc.identifier.volume22en_US
dc.identifier.wosWOS:000236765000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadenosine deaminaseen_US
dc.subjectcisplatin nephrotoxicityen_US
dc.subjectginkgo bilobaen_US
dc.subjectmalondialdehydeen_US
dc.subjectmyeloperoxidaseen_US
dc.subjectnitric oxideen_US
dc.subjectxanthine oxidaseen_US
dc.titleThe effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicityen_US
dc.typeArticleen_US

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