Protective effects of erdosteine on rotenone-induced oxidant injury in liver tissue

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dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.contributor.authorTerzi, A
dc.contributor.authorIraz, M
dc.contributor.authorSahin, S
dc.contributor.authorIlhan, A
dc.contributor.authorIdiz, N
dc.contributor.authorFadillioglu, E
dc.date.accessioned2024-08-04T20:14:44Z
dc.date.available2024-08-04T20:14:44Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRotenone, an insecticide of botanical origin, causes toxicity through inhibition of complex I of the respiratory chain in mitochondria. This study was undertaken to determine whether rotenone-induced liver oxidant injury is prevented by erdosteine, a mucolytic agent showing antioxidant properties. There were four groups of Male Wistar Albino rats: group one was untreated as control; the other groups were treated with erdosteine (50 mg/kg per day, orally), rotenone (2.5 mg/mL once and 1 mL/kg per day for 60 days, i.p.) or rotenone plus erdosteine, respectively. Rotenone treatment without erdosteine increased xanthine oxidase (XO) enzyme activity and also increased lipid peroxidation in liver tissue (P < 0.05). The rats treated with rotenone plus erdosteine produced a significant decrease in lipid peroxidation and XO activities in comparison with rotenone group (P < 0.05). Erdosteine treatment with rotenone led to an increase in catalase (CAT) and superoxide dismutase (SOD) activities in comparison with the rotenone group (P < 0.05). There was no significant difference in nitric oxide (NO) level between groups. There were negative correlations between CAT activity and malondialdehyde (MDA) level (r = -0.934, P < 0.05) with between CAT and SOD activities (r = -0.714, P < 0.05), and a positive correlation between SOD activity and MDA level (r = 0.828, P < 0.05) in rotenone group. In the rotenone plus erdosteine group, there was a negative correlation between XO activity and NO level in liver tissue (r = -0.833, P < 0.05). In the light of these findings, erdosteine may be a protective agent for rotenone-induced liver oxidative injury in rats.en_US
dc.identifier.doi10.1191/0748233704th208oa
dc.identifier.endpage147en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue6-10en_US
dc.identifier.pmid15941011en_US
dc.identifier.scopus2-s2.0-18744371603en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1191/0748233704th208oa
dc.identifier.urihttps://hdl.handle.net/11616/93937
dc.identifier.volume20en_US
dc.identifier.wosWOS:000229288100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidantsen_US
dc.subjecterdosteineen_US
dc.subjectlipid peroxidationen_US
dc.subjectliveren_US
dc.subjectrotenoneen_US
dc.titleProtective effects of erdosteine on rotenone-induced oxidant injury in liver tissueen_US
dc.typeArticleen_US

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