Serum cytokine changes in Turkish children infected with Giardia lamblia with and without allergy

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dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorBayraktar, MR
dc.contributor.authorMehmet, N
dc.contributor.authorDurmaz, R
dc.date.accessioned2024-08-04T20:14:49Z
dc.date.available2024-08-04T20:14:49Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present report is a case control study aimed to determine the levels of cytokines and other parameters in the sera of allergy-complicated and uncomplicated giardiasic children before and after metronidazole treatment. The study included a total of 126 subjects; 52 giardiasic children, 34 allergy-complicated giardiasis (36.9%) and 34 healthy controls, as well as six cases of giardiasis simultaneously infected with other parasites or bacterial pathogens. Serum levels of tumor necrosis factor-alpha (TNF-alpha) interleukin (IL)-1 beta, soluble IL-2 receptor (sIL-2R), IL-6, IL-8, nitric oxide (NO), and C-reactive protein (CRP) were determined. TNF-alpha and sIL-2R levels significantly increased in giardiasic cases. IL-1 beta, IL-6, IL-8, CRP, and NO levels increased only in the cases associated with allergy. All increased variables significantly decreased following metronidazole treatment and returned to normal levels. Metronidazole-treated patients became 100% parasite free. In conclusion, increased TNF-alpha and sIL-2R may be involved in pathogenesis of non-allergic giardiasis and probably Th1 type immune response seems to be predominant and this response may be protective rather than causative of the disease. Activation of the immune system takes place in giardiasis. It is broader and more intense in allergy-complicated giardiasis than that of uncomplicated cases, most probably due to non-invasive character of G. lamblia. Enhanced IgE production pointed to Th2-type immune response and confirms its association with allergy. (C) 2005 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.actatropica.2005.05.006
dc.identifier.endpage122en_US
dc.identifier.issn0001-706X
dc.identifier.issn1873-6254
dc.identifier.issue2en_US
dc.identifier.pmid15979046en_US
dc.identifier.scopus2-s2.0-21744461468en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.1016/j.actatropica.2005.05.006
dc.identifier.urihttps://hdl.handle.net/11616/93994
dc.identifier.volume95en_US
dc.identifier.wosWOS:000230867100006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofActa Tropicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgiardiasisen_US
dc.subjectcytokinesen_US
dc.subjectCRPen_US
dc.subjectNOen_US
dc.subjectallergyen_US
dc.subjectmetronidazoleen_US
dc.titleSerum cytokine changes in Turkish children infected with Giardia lamblia with and without allergyen_US
dc.typeArticleen_US

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