Phytochemical stability and bioavailability of black mulberry, chokeberry, and elderberry during gastrointestinal digestion and their implications for human nutrition

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dc.contributor.authorZengin, Rukiye
dc.contributor.authorUgur, Yilmaz
dc.contributor.authorErdogan, Selim
dc.contributor.authorHatterman-Valenti, Harlene
dc.contributor.authorKaya, Ozkan
dc.date.accessioned2026-04-04T13:31:22Z
dc.date.available2026-04-04T13:31:22Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractUnderstanding the fate of bioactive compounds during human digestion is crucial for translating berry consumption into actual health benefits. In this study, we investigated the effects of different digestion methods and gastrointestinal environments on the phytochemical content and antioxidant capacity of the black mulberry (BMF), chokeberry (CF), and Elderberry (EF) fruit and leaf samples. Pre-digest and digest methods were applied to evaluate changes in phenolic compounds and antioxidant capacity under simulated oral, gastric, and intestinal conditions. Based on our findings, elderberry demonstrated the highest total phenolic content in the intestinal phase (44.0 mg GAE/g), while chokeberry showed the highest antioxidant capacity, with cupric reducing antioxidant capacity (CUPRAC) values of 134.3 mg TE/g and 2,2 '-azinobis (3-ethylbenzothiazoline 6-sulfonate) (ABTS) of 104.8 mg TE/g. Anthocyanin stability analysis revealed severe degradation of cyanidin-3-O-glucoside during digestion, with reductions of 68.9%, 70.4%, and 82.7% in oral, gastric, and intestinal phases respectively from initial concentrations of 2106.12 mg/100g. Notably, quercetin content increased dramatically from 0.8-0.9 mg/100g to 16.8 mg/100g in BMF during intestinal digestion, while catechin showed substantial reduction from 1151.4 mg/100g in elderberry samples. This research elucidates the complex dynamics of phytochemical stability and bioavailability during gastrointestinal digestion, providing valuable insights for understanding the potential health benefits of these berries in human nutrition and suggesting opportunities for developing targeted delivery systems to enhance the stability of beneficial compounds throughout the digestive process.
dc.description.sponsorshipCoordination Unit of Inonu University [TDK-2021-2385]
dc.description.sponsorshipThe Scientific Research and Coordination Unit of Inonu University provided support for this work (Project Number: TDK-2021-2385).
dc.identifier.doi10.25259/JKSUS_644_2025
dc.identifier.issn1018-3647
dc.identifier.issn2213-686X
dc.identifier.issue6
dc.identifier.orcid0000-0002-9040-4249
dc.identifier.scopus2-s2.0-105019204696
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.25259/JKSUS_644_2025
dc.identifier.urihttps://hdl.handle.net/11616/108766
dc.identifier.volume37
dc.identifier.wosWOS:001627959000002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScientific Scholar Llc
dc.relation.ispartofJournal of King Saud University Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAntioxidant capacity
dc.subjectAnthocyanin stability
dc.subjectBioactive compounds
dc.subjectGastrointestinal digestion
dc.subjectPhenolic compounds
dc.titlePhytochemical stability and bioavailability of black mulberry, chokeberry, and elderberry during gastrointestinal digestion and their implications for human nutrition
dc.typeArticle

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