BK virus incidence, risk factors and its effect on mortality in hematopoietic stem cell transplant patients-single center experience

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dc.contributor.authorDeviren, Mehmet Veysi
dc.contributor.authorSarıcı, Ahmet
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorBahçecioğlu, Ömer Faruk
dc.contributor.authorBiçim, Soykan
dc.contributor.authorBerber, İlhami
dc.contributor.authorKaya, Emin
dc.date.accessioned2024-08-04T19:53:17Z
dc.date.available2024-08-04T19:53:17Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this trial is to investigate the risk factors of BK viruria and the effect of BK viruria on mortality in patients undergoing hematopoietic stem cell transplantation (HSCT). The data of 247 patients who underwent HSCT between 01.01.2011-01.12.2017 in Inonu University Faculty of Medicine Department of Hematology were retrospectively analyzed. BK viruria was defined as positive at any copy level in the urine. Of 247 patients, 97 patients (39.2%) were detected to have BK virus-posi- tive. Patients with positive BK virus in urine were younger than BK virus negative patients, and patients with multiple myeloma had a lower rate of BK virus positivity than other patients (p<0.05). The rate of BK viruria was found to be higher in patients who received busulfan and cyclophosphamide-containing conditioning regimens compared to patients who received other conditioning regimens (46% vs 28.9%, p=0.007). In addition, BK virus positivity was found to be lower in those receiving mel- phalan-based conditioning regimens than those receiving other conditioning regimes (28.6% vs 47.2%, p=0.008). BK virus positivity in urine was detected median 20 days after HSCT. BK virus positivity was detected in 80.4% (78/97) of the patients within the first 30 days. Patients with BK viruria had a higher first 100-day mortality than patients without BK viruria (17.5% vs 8%, p=0.023). In this series, BK viruria is a factor associated with mortality in the early period after HSCT and should be closely monitored in these patients.en_US
dc.identifier.doi10.5455/medscience.2021.02.040
dc.identifier.endpage859en_US
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage856en_US
dc.identifier.trdizinid1188099en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2021.02.040
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1188099
dc.identifier.urihttps://hdl.handle.net/11616/89650
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleBK virus incidence, risk factors and its effect on mortality in hematopoietic stem cell transplant patients-single center experienceen_US
dc.typeArticleen_US

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