Can T2 blackout effect be a marker of iron accumulation in brains of multiple sclerosis patients?

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dc.authoridERBAY, MEHMET FATİH/0000-0002-1596-3147
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authorwosidERBAY, MEHMET FATİH/ABI-2942-2020
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidKamisli, Ozden/JVZ-0145-2024
dc.contributor.authorErbay, Mehmet Fatih
dc.contributor.authorKamisli, Ozden
dc.contributor.authorKaratoprak, Nur Betul
dc.date.accessioned2024-08-04T20:48:49Z
dc.date.available2024-08-04T20:48:49Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective : T2 blackout (TBO) effect, which is a common finding in the brains of multiple sclerosis (MS) patients and older population that are imaged for other reasons on diffusion weighted imagings (DWI) and apparent diffusion coefficient (ADC) map show the existence of paramagnetic materials in the tissue. Because iron is known to accumulate in especially deep gray matter (DGM) structures in MS brains, we aimed to investigate the relationship between TBO and clinico-radiological parameters that may be iron-related in MS. Methods: We retrospectively reviewed the latest MR images of MS patients on 3 Tesla MR scanner between 2018 and 2019. TBO existence and severity on DWI-ADC was assessed by two radiologists and its correlation with several outcomes of MS was investigated. Results: No significant relationship was found between TBO and gender, subtype of MS whereas TBO was positively correlated with parameters such as black-hole lesions, cortical atrophy, duration of disease, age and extended disability status scale (EDSS) score. Conclusions: TBO shows correlation with the conditions which were revealed to be associated with iron accumulation in the brain of MS patients in the literature. Therefore, we concluded that TBO and its severity in DGM may represent iron accumulation in MS brains. Advances in knowledge: TBO effect as a frequent imaging finding in daily practice may be used as predictor of the disease course of MS due to possible effects of iron accumulation in brain and thereby may be useful in modifying treatment strategies.en_US
dc.identifier.doi10.1259/bjr.20200552
dc.identifier.issn0007-1285
dc.identifier.issn1748-880X
dc.identifier.issue1113en_US
dc.identifier.pmid32614611en_US
dc.identifier.scopus2-s2.0-85089768372en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1259/bjr.20200552
dc.identifier.urihttps://hdl.handle.net/11616/99477
dc.identifier.volume93en_US
dc.identifier.wosWOS:000561487500027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBritish Inst Radiologyen_US
dc.relation.ispartofBritish Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeep Gray-Matteren_US
dc.subjectSusceptibilityen_US
dc.subjectMrien_US
dc.subjectHypointensityen_US
dc.subjectProgressionen_US
dc.subjectHolesen_US
dc.titleCan T2 blackout effect be a marker of iron accumulation in brains of multiple sclerosis patients?en_US
dc.typeArticleen_US

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