Is there a relationship between vitamin D levels and graft versus host disease?

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dc.contributor.authorYigenoglu, Tugce Nur
dc.contributor.authorUlu, Bahar Uncu
dc.contributor.authorNamdaroglu, Sinem
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorSahin, Rasim
dc.contributor.authorOkumus, Nazik
dc.contributor.authorYilmaz, Seda
dc.date.accessioned2026-04-04T13:34:50Z
dc.date.available2026-04-04T13:34:50Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: Vitamin D deficiency is common in adult patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT). Since vitamin D is an important regulatory factor for the immune system, vitamin D deficiency may have effects on antitumor activity, relapse rates, graft versus host disease (GVHD) occurrence and infection rates in allo-HSCT. We aimed to investigate the effects of vitamin D levels on the outcome of allo-HSCT. Material and methods: This study included 211 patients who underwent allo-HSCT at seven transplant centers in T & uuml;rkiye. The impact of pretransplant vitamin D level on overall survival (OS), relapse rate, GVHD occurrence and engraftment times was analyzed retrospectively Results: Pretransplant vitamin D levels were not related to the neutrophil engraftment day (p: 0.887), relapse rate (p: 0.433) and GVHD occurrence (p: 0.391). At a median follow-up of 14 months, OS was 84.8 % and median OS was not reached. Univariate Cox Regression analysis showed that higher levels of vitamin D (>12 ng/mL) affected the survival rates (p = 0.029) (HR: 0.392: 95 % CI: 10.170-0.907). Conclusion: In our study, pretransplant vitamin D levels were not related to GVHD occurrence, relapse rate and engraftment times. However, we found that higher levels of pretransplant vitamin D levels (threshold is 12 ng/ mL) were associated with increased survival. Further studies with a larger population are necessary to reveal the role of vitamin D in patients undergoing allo-HSCT.
dc.identifier.doi10.1016/j.transci.2024.104054
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue1
dc.identifier.orcid0000-0003-3173-7614
dc.identifier.orcid0000-0001-6872-3780
dc.identifier.orcid0000-0002-3285-417X
dc.identifier.orcid0000-0002-6230-9519
dc.identifier.orcid0000-0002-7222-499X
dc.identifier.pmid39709787
dc.identifier.scopus2-s2.0-85212619924
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.transci.2024.104054
dc.identifier.urihttps://hdl.handle.net/11616/109409
dc.identifier.volume64
dc.identifier.wosWOS:001395124800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofTransfusion and Apheresis Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAllogeneic hematopoietic stem cell
dc.subjecttransplantation
dc.subjectVitamin D
dc.subjectGraft vs host disease
dc.titleIs there a relationship between vitamin D levels and graft versus host disease?
dc.typeArticle

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