Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats

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dc.authoridYagin, Fatma Hilal/0000-0002-9848-7958
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authorwosidYagin, Fatma Hilal/ABI-8066-2020
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.contributor.authorGurler, Mukaddes
dc.contributor.authorSelcuk, Engin Burak
dc.contributor.authorOzerol, Beyza Guzide
dc.contributor.authorTanbek, Kevser
dc.contributor.authorTaslidere, Elif
dc.contributor.authorYildiz, Azibe
dc.contributor.authorYagin, Fatma Hilal
dc.date.accessioned2024-08-04T20:52:03Z
dc.date.available2024-08-04T20:52:03Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMethotrexate is a familiar chemotherapeutic preferred in a wide range of clinical fields such as leukemia, psoriasis, rheumatoid arthritis, neoplastic and autoimmune disorders. However, methotrexate therapy has limitations as it causes severe side effects from which liver damage is the most important one. Several antioxidant compounds have been studied against methotrexate related liver toxicity, but dexpanthenol has not been experienced. Vitamin B5-derived dexpanthenol is a usual therapeutic having a potent anti-inflammatory and antioxidant effect. In this study, we aimed to evaluate the ameliorating effect of dexpanthenol against methotrexate-induced hepatotoxicity. We performed our experiments on Wistar albino rats divided randomly into four groups involving control, dexphantenol, dexpanthenol + methotrexate and methotrexate applied animals. After this experimental work on rats, for the first time, we showed dexpanthenol improvement effect on ROS-caused hepatotoxicity initiated by methotrexate administration in terms of liver tissue antioxidant/oxidant enzymes, liver function tests, and histological changes. We suggest that dexpanthenol might be applied during methotrexate treatment in order to reduce the liver toxicity. However, further studies are needed to find out the optimal dose regimen and to understand the mechanism of action.en_US
dc.identifier.doi10.1080/01480545.2022.2084103
dc.identifier.endpage716en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue4en_US
dc.identifier.pmid35655424en_US
dc.identifier.scopus2-s2.0-85131582304en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage708en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2022.2084103
dc.identifier.urihttps://hdl.handle.net/11616/100705
dc.identifier.volume46en_US
dc.identifier.wosWOS:000805675900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethotrexate-induced hepatotoxicityen_US
dc.subjectoxidative damageen_US
dc.subjectdexpanthenolen_US
dc.subjectantioxidant systemen_US
dc.subjectoxidative stressen_US
dc.titleProtective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in ratsen_US
dc.typeArticleen_US

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