Discordance among aggressiveness characteristics of hepatocellular carcinoma: Portal vein thrombosis and multifocality, related to tumor size, but not to serum alpha-fetoprotein level

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dc.authoridCarr, Brian/0000-0002-6111-5077
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.contributor.authorCarr, Brian I.
dc.contributor.authorGuerra, Vito
dc.contributor.authorInce, Volkan
dc.contributor.authorIsik, Burak
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:54:40Z
dc.date.available2024-08-04T20:54:40Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and aims: Hepatocellular carcinoma (HCC) is characterized by several clinically important prognostic parameters, including portal vein thrombosis (PVT), tumor multifocality, and serum alpha-fetoprotein (AFP) levels, in addition to maximum tumor diameter (MTD). However, associations among these parameters have not been thoroughly examined. Thus, the study aimed to investigate the correlations among these HCC characteristics in a prospectively collected database.Methods: An 8080 HCC patient database derived from our weekly HCC council meeting was examined with respect to the correlations at baseline patient presentation between increases in MTD and changes in the percentage of patients with PVT, multifocality, or AFP levels.Results: The percentage of patients with PVT and with multifocality (tumor nodule numbers >= 3) significantly increased with enlarging MTD, regardless of the serum AFP level, showing the indepen-dence of PVT and multifocality on AFP. The percentage of patients with multifocality increased with enlarging MTD, in the presence or absence of PVT, showing the independence of multifocality from PVT. Therefore, discordance was found between different tumor parameters.Conclusions: A statistically significant association was found between PVT and MTD and between mul-tifocality and MTD, all three of which are independent of AFP. PVT and multifocality appeared to be independent of each other. Although PVT and multifocality were independent of AFP, they were also augmented with high serum AFP levels. The results suggest the possibility of multiple pathways of tumor progression in the later stages of HCC development.(c) 2023 The Third Affiliated Hospital of Sun Yat-sen University. Publishing services by Elsevier B. V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work was supported in part by NIH grant CA 82723 (Brian I. Carr).en_US
dc.identifier.doi10.1016/j.livres.2023.07.003
dc.identifier.endpage262en_US
dc.identifier.issn2096-2878
dc.identifier.issn2542-5684
dc.identifier.issue3en_US
dc.identifier.pmid37854945en_US
dc.identifier.scopus2-s2.0-85170668443en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage256en_US
dc.identifier.urihttps://doi.org/10.1016/j.livres.2023.07.003
dc.identifier.urihttps://hdl.handle.net/11616/101569
dc.identifier.volume7en_US
dc.identifier.wosWOS:001086626600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKeai Publishing Ltden_US
dc.relation.ispartofLiver Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatocellular carcinoma (HCC)en_US
dc.subjectPortal vein thrombosis (PVT)en_US
dc.subjectMultifocalityen_US
dc.subjectAlpha-fetoprotein (AFP)en_US
dc.subjectHeterogeneityen_US
dc.titleDiscordance among aggressiveness characteristics of hepatocellular carcinoma: Portal vein thrombosis and multifocality, related to tumor size, but not to serum alpha-fetoprotein levelen_US
dc.typeArticleen_US

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