PREPARATION OF A POLYURETHANE MEMBRANE TESTOSTERONE SENSOR AND ITS APPLICATION USING SQUARE-WAVE STRIPPING VOLTAMMETRY

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dc.authoridgungor, oznur/0000-0002-0664-1218
dc.contributor.authorHarman, Cemre Zeynep
dc.contributor.authorGungor, Oznur
dc.date.accessioned2024-08-04T20:52:13Z
dc.date.available2024-08-04T20:52:13Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA novel electrochemical sensor for testosterone detection has been prepared by the chemical modification of a gold electrode (AuE). For the electrode modification, specific polyurethane (PU) films were synthesized from hexamethylene diisocyanate, olivetol, polyethylene glycol-100 (PEG100) and beta-cyclodextrin. The synthesized PUs were investigated as selective films, and were used to coat a AuE surface at different concentrations and thicknesses. The testosterone responses of the modified electrodes were investigated by square-wave voltammetry (SWV). One separated cathodic SWV peak was obtained for testosterone at -0.390 V, with the prepared PU-modified AuE in 0.1 M phosphate buffer (PB) (pH 7.2). The linearity of testosterone responses of the prepared PU modified electrode was obtained over a concentration range of 0.1-1.0 mu M (R-2 = 0.995). It was observed that the response of the electrode increased regularly and sensitively with increasing testosterone amount. The detection limit, relative standard deviation and sensitivity of modified electrode were found to be approximately 5.69 nM, 1.669 % and 98.331 %, respectively. The PU-modified AuE exhibited good selectivity and a low response time for testosterone. Therefore, the prepared testosterone sensor offers a good alternative for fast and practical testosterone determination in clinical or biomedical studies.en_US
dc.description.sponsorshipTUBITAK -Directorate of Science Fellowships and Grant Programmes (BIDEB) (2209 A)en_US
dc.description.sponsorshipThis project was financially supported by TUBITAK -Directorate of Science Fellowships and Grant Programmes (BIDEB) (2209 A).en_US
dc.identifier.doi10.20450/mjcce.2022.2493
dc.identifier.issn1857-5552
dc.identifier.issn1857-5625
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85134717636en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.20450/mjcce.2022.2493
dc.identifier.urihttps://hdl.handle.net/11616/100801
dc.identifier.volume41en_US
dc.identifier.wosWOS:000807380700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Chemists Technologists Madeconiaen_US
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttestosteroneen_US
dc.subjectsensoren_US
dc.subjectpolyurethane membranesen_US
dc.subjectsquare-wave voltammetryen_US
dc.titlePREPARATION OF A POLYURETHANE MEMBRANE TESTOSTERONE SENSOR AND ITS APPLICATION USING SQUARE-WAVE STRIPPING VOLTAMMETRYen_US
dc.typeArticleen_US

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