Sitagliptin Alleviates Radiation-Induced Kidney and Testis Degeneration in Rats

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dc.contributor.authorCelik, Huseyin
dc.contributor.authorTemelli, Oztun
dc.contributor.authorOzhan, Onural
dc.contributor.authorTaslidere, Elif
dc.contributor.authorDogru, Feyzi
dc.date.accessioned2026-04-04T13:31:12Z
dc.date.available2026-04-04T13:31:12Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Radiation-induced tissue degeneration is the most important side effect of radiotherapy. Sitagliptin with its anti-inflammatory and antioxidant capacity was tested in alleviating the radiation-induced cellular degeneration in kidney and testis tissues. Methods: Wistar albino rats were divided into four groups as control, radiation (RT), radiation + sitagliptin (RT + SGT), and sitagliptin + radiation (SGT + RT). The RT group received 8 Gy radiation. Sitagliptin was applied per os at a 10 mg/kg dose for 14 days to the SGT groups either after or before radiation. Results: Radiation induced marked oxidative stress in kidney and testis tissues, whereas sitagliptin partially restored several antioxidant parameters in the kidney and reduced MDA levels in the testis. Histologically, radiation caused degenerative changes in the renal tubules and glomerulus and the testicular seminiferous tubules, while sitagliptin treatment attenuated these changes in both organs. Caspase-3 expression increased significantly after radiation treatment in the kidney without substantial improvement by sitagliptin; however, VEGF expression, which was markedly reduced by radiation in both tissues, was restored in sitagliptin-treated groups. FGF expression suppressed in all irradiated groups as compared to the control with no significant differences among them. Conclusions: Overall, the results indicated that sitagliptin can be used to attenuate the degenerative effects induced by radiation. Sitagliptin use after radiation as compared to the before use showed significantly better results especially in the kidney tissue.
dc.description.sponsorshipInonu University Scientific Research Project Unit [TSA-2023-3263]
dc.description.sponsorshipThis research was funded by the Inonu University Scientific Research Project Unit, grant number TSA-2023-3263.
dc.identifier.doi10.3390/biom15121702
dc.identifier.issn2218-273X
dc.identifier.issue12
dc.identifier.orcid0000-0001-9018-7849
dc.identifier.orcid0000-0003-3471-1284
dc.identifier.orcid0000-0002-7949-9582
dc.identifier.pmid41463358
dc.identifier.scopus2-s2.0-105025641776
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/biom15121702
dc.identifier.urihttps://hdl.handle.net/11616/108649
dc.identifier.volume15
dc.identifier.wosWOS:001646876900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofBiomolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectsitagliptin
dc.subjectradiation
dc.subjectapoptosis
dc.subjectoxidative stress
dc.subjecthistopathology
dc.titleSitagliptin Alleviates Radiation-Induced Kidney and Testis Degeneration in Rats
dc.typeArticle

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