In vitro antioxidant and antimicrobial activities and therapeutic effects of Rhizopogon luteolus Fr. extract on cecal ligation and puncture-induced sepsis in rats

Basit Öğe Kaydı
dc.contributor.authorOzhan, Onural
dc.contributor.authorYildiz, Azibe
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorGunal, Selami
dc.contributor.authorVardi, Nigar
dc.contributor.authorAtes, Burhan
dc.contributor.authorGunata, Mehmet
dc.date.accessioned2026-04-04T13:35:16Z
dc.date.available2026-04-04T13:35:16Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground The purpose of this research was to determine how Rhizopogon luteolus extract (RLE) affects rat cecal ligation and puncture (CLP)-induced sepsis. Methods Wistaralbino rats were randomly assigned to six groups (n = 8). (1) Sham group; (2) CLP group; (3) CLP+1% RLE group; (4) CLP+5% RLE group; (5) CLP+10% RLE group; (6) CLP+25% RLE group. Rat liver, kidney, ileum, and lung tissues were examined histologically and biochemically. Results The degree of infiltration in the lung, liver, ileum, and renal tissues was substantially lower in the CLP+10% RLE group than in the CLP group. With the exception of the kidneys, all tissues in the CLP+25% RLE group showed substantial histological improvement. Compared with the CLP group, the CLP group presented considerable reductions in mucosal epithelial degeneration and desquamation. The increased malondialdehyde levels in the liver, kidney and ileum tissues of the sepsis-induced groups were significantly lower than those in the RLE-treated groups by 5% or more. The decreased glutathione and catalase activities in the ileum tissues of the CLP groups significantly increased in the RLE-treated groups by 5% and above. The decrease in superoxide dismutase levels in the liver and kidney tissues of the sepsis-induced injury group increased significantly in the groups with 5% RLE in the liver tissue and 1% RLE in the kidney tissue. Conclusion RLE, which has been proven by in vitro studies, has therapeutic effects on the lung, liver, kidney and ileum tissues of rats with sepsis caused by CLP. Among the doses tested, 10% RLE exhibited the most consistent and significant protective effects in reducing histopathological damage and restoring antioxidant balance in sepsis-affected tissues.
dc.description.sponsorshipResearch Fund of Inonu University [2016/188]
dc.description.sponsorshipThis work was supported by the Research Fund of & Idot;noenue University. (Project number: 2016/188 belongs to Parlakpinar H.).
dc.identifier.doi10.1007/s42452-025-07620-y
dc.identifier.issn3004-9261
dc.identifier.issue10
dc.identifier.orcid0000-0001-9018-7849
dc.identifier.orcid0000-0001-6905-4259
dc.identifier.orcid0000-0003-0724-4772
dc.identifier.orcid0000-0002-4752-5176
dc.identifier.orcid0000-0001-9497-3468
dc.identifier.orcid0000-0001-6080-229X
dc.identifier.scopus2-s2.0-105017492690
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s42452-025-07620-y
dc.identifier.urihttps://hdl.handle.net/11616/109735
dc.identifier.volume7
dc.identifier.wosWOS:001582498100017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofDiscover Applied Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectCecal ligation
dc.subjectRhizopogon luteolus
dc.subjectSepsis
dc.titleIn vitro antioxidant and antimicrobial activities and therapeutic effects of Rhizopogon luteolus Fr. extract on cecal ligation and puncture-induced sepsis in rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu