MRSA genotypes in Turkey: Persistence over 10 years of a single clone of ST239

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dc.authoridAlp Meşe, Emine/0000-0003-0189-6008
dc.authoridÖzakın, Cüneyt/0000-0001-5428-3630
dc.authoridDoganay, Mehmet/0000-0003-3922-4901
dc.authoridKlaassen, Corné/0000-0002-3439-0903;
dc.authorwosidAlp Meşe, Emine/AET-7752-2022
dc.authorwosidTurhan, Özge/C-1007-2016
dc.authorwosidÖzakın, Cüneyt/AAG-8392-2021
dc.authorwosidVoss, A./H-8111-2014
dc.authorwosidDoganay, Mehmet/G-4250-2019
dc.authorwosidKlaassen, Corné/A-2739-2012
dc.authorwosidAltoparlak, Ulku/JPW-9712-2023
dc.contributor.authorAlp, Emine
dc.contributor.authorKlaassen, Corne H. W.
dc.contributor.authorDoganay, Mehmet
dc.contributor.authorAltoparlak, Ulku
dc.contributor.authorAydin, Kemalettin
dc.contributor.authorEngin, Aynur
dc.contributor.authorKuzucu, Cigdem
dc.date.accessioned2024-08-04T20:31:14Z
dc.date.available2024-08-04T20:31:14Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of life-threatening human infections. The clinical impact of MRSA is mounting, not only due to the ever-increasing prevalence but also due to the occurrence of new, community-acquired MRSA strains. The aim of this prospective, multi-centre study was to determine the prevalence and genetic relatedness of clinically relevant MRSA isolates, in Turkey. Methods: During a 1-year period, data from 20 successive patients with invasive S. aureus infections were collected from eight university hospitals, geographically distributed over the six main regions of Turkey. Among these S. aureus isolates, the genetic association of MRSA isolates was investigated by pulsed-field get electrophoresis (PFGE) and spa typing. A selected number of isolates were also analyzed by multilocus sequence typing (MLST). Furthermore, Panton Valentine leucocidin (PVL) genes were examined. Results: In this study, the rate of methicillin resistance in S. aureus in patients with apparent infections (sepsis, meningitis, lung abscess or septic arthritis) ranged from 12 to 75% within the seven participating centres. Typing by pulsed-field get electrophoresis and spa typing revealed the presence of 22 closely related genotypes. According to the PFGE and spa typing results, 53 out of 54 MRSA isolates were closely related. These isolates were of spa type t030 or a related spa type, contain an SCC mec type III element and belong to sequence type ST239. None of the isolates contained the PVL genes. Conclusions: Despite the broad surface area of Turkey, a single predominant clone of ST239 circulates in hospitals in different regions and only few new types of MRSA were introduced over the past years. These results place Turkey in the epicenter of ST239 prevalence. (C) 2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jinf.2009.04.006
dc.identifier.endpage438en_US
dc.identifier.issn0163-4453
dc.identifier.issue6en_US
dc.identifier.pmid19446883en_US
dc.identifier.scopus2-s2.0-65649152538en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage433en_US
dc.identifier.urihttps://doi.org/10.1016/j.jinf.2009.04.006
dc.identifier.urihttps://hdl.handle.net/11616/94800
dc.identifier.volume58en_US
dc.identifier.wosWOS:000267297400005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofJournal of Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethicillin-resistant Staphylococcus aureusen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectPanton Valentine leucocidin genesen_US
dc.titleMRSA genotypes in Turkey: Persistence over 10 years of a single clone of ST239en_US
dc.typeArticleen_US

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