Analysis of the Population Genetic Structure of Hb D-Los Angeles [?121 (GH4) Glu?Gln GAA?CAA] in Denizli, Turkey; Genetic Diversity, Historical Demography and Estimation of the Mutation Rates Based on Haplotype Variation

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dc.authoridOZTURK, Onur/0000-0003-3404-4135
dc.authorwosidArıkan, Sanem/ABI-6170-2020
dc.authorwosidOZTURK, Onur/HLH-4990-2023
dc.contributor.authorOzturk, Onur
dc.contributor.authorArikan, Sanem
dc.contributor.authorAtalay, Ayfer
dc.contributor.authorAtalay, Erol O.
dc.date.accessioned2024-08-04T20:43:57Z
dc.date.available2024-08-04T20:43:57Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Understanding the genetic origin of the Hb D-Los Angeles hemoglobin may elucidate population interactions such as movements, migrations, and environmental effects on mutation mechanisms in human biology throughout history. Our study aimed to understand the genetic origin of Hb D-Los Angeles based on haplotype data, observed in the Denizli province of Turkey. Methods: We studied DNA samples from 40 unrelated patients with abnormal hemoglobin Hb D-Los Angeles and 59 unrelated healthy subjects from our DNA bank. Possible associated haplotypes, HWE, genetic diversity and population differentiation, population genetic structure analysis and historical-demographic analysis for the two populations were determined by Arlequin ver. 3.5. Results: Molecular diversity results from the two populations show that both populations are genetically similar as far as development and expansion during the historical period. Historical gene flow results show high gene flow between the two populations. SSD and rg tests failed to reject the null hypothesis of population expansion which is consistent with unimodal distribution. Our estimated tau values show that the average time since the demographic expansion for normal and Hb D-Los Angeles populations ranged from approximately 42,000-38,000 ybp, respectively. Conclusions: Our data suggest that the Hb D-Los Angeles population originated within the normal population in Denizli, Turkey. Our results support the hypothesis that the Hb D-Los Angeles mutation may have originated in the Mediterranean area, independent from other populations such as India and China. The evaluation of such data may contribute valuable information to anthropological, paleoclimatic, archaeological, and phylogeographical approaches to human biology throughout the historical period. (C) 2015 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/ajhb.22816
dc.identifier.endpage483en_US
dc.identifier.issn1042-0533
dc.identifier.issn1520-6300
dc.identifier.issue4en_US
dc.identifier.pmid26680249en_US
dc.identifier.scopus2-s2.0-85028241734en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage476en_US
dc.identifier.urihttps://doi.org/10.1002/ajhb.22816
dc.identifier.urihttps://hdl.handle.net/11616/97943
dc.identifier.volume28en_US
dc.identifier.wosWOS:000383684900004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAmerican Journal of Human Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHuman Mitochondrial-Dnaen_US
dc.subjectD-Punjaben_US
dc.subjectCluster Haplotypesen_US
dc.subjectBeta-Thalassemiaen_US
dc.subjectPolymorphismen_US
dc.subjectHypothesisen_US
dc.subjectDistancesen_US
dc.subjectDiagnosisen_US
dc.subjectProvinceen_US
dc.subjectAllelesen_US
dc.titleAnalysis of the Population Genetic Structure of Hb D-Los Angeles [?121 (GH4) Glu?Gln GAA?CAA] in Denizli, Turkey; Genetic Diversity, Historical Demography and Estimation of the Mutation Rates Based on Haplotype Variationen_US
dc.typeArticleen_US

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