Beneficial effects of nerolidol on thioacetamide-induced damage of the reproductive system in male rats

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dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridCAMTOSUN, Ahmet/0000-0002-5390-9088
dc.authoridGurbuz, Sukru/0000-0003-2616-0304
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidçelik, hüseyin/AAA-3033-2021
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidCAMTOSUN, Ahmet/ABI-8300-2020
dc.authorwosidGurbuz, Sukru/ABI-3276-2020
dc.contributor.authorCelik, Huseyin
dc.contributor.authorCamtosun, Ahmet
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorAydin, Muhterem
dc.contributor.authorGurbuz, Sukru
dc.date.accessioned2024-08-04T20:42:32Z
dc.date.available2024-08-04T20:42:32Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, it was aimed to determinate beneficial effects of Nerolidol (NLR) against reproductive toxicity caused by Thioacetamide (TAA). Male, 3-4-months-old, rats (n=32) were divided into four groups. Group-1 was kept as control and given corn oil as carrier. Group-2 received TAA (200 mg/kg, intraperitoneal (i.p.), two times per week) for 3 weeks, in group-3; NRL was orally administered at the dose of 100 mg/kg per every other day by gavages, group-4; 200 mg/kg TAA and 100 mg/kg NRL were given. Thiobarbituric Acid Reactive Substances (TBARS) and reduced Glutathione (GSH) levels, Catalase (CAT), Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX), sperm parameters and reproductive organs weight were determined. TAA caused a significant rise in TBARS level and a significant reduce in GPX, CAT, SOD and GSH levels in the testicular tissues compared with the control group, while NLR led to significant reduce in lipid peroxidation via decreasing TBARS level and increasing the levels of GPX, CAT, SOD and GSH. Besides, sperm parameters significantly reduced, and pathologic testicular damage increased with TAA exposure. However, these effects of TAA on sperm parameters and histopathological changes were reversed by NLR treatment. In conclusion, our results demonstrate that the management of TAA induced the testicular damage and NLR prevented thioacetamide-induced testicular damage in rats.en_US
dc.identifier.endpage730en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84979008662en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage725en_US
dc.identifier.urihttps://hdl.handle.net/11616/97432
dc.identifier.volume27en_US
dc.identifier.wosWOS:000388456100023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerolidolen_US
dc.subjectThioacetamideen_US
dc.subjectRaten_US
dc.subjectExperimentalen_US
dc.subjectTesticular damageen_US
dc.titleBeneficial effects of nerolidol on thioacetamide-induced damage of the reproductive system in male ratsen_US
dc.typeArticleen_US

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