Predictors of local control after robotic stereotactic radiotherapy for brain metastases: 10-years-experience after Cyberknife installation

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dc.authoridGunbey, HP/0000-0001-5288-5590
dc.authoridDOGAN, BEDRIYE/0000-0002-8726-3801
dc.authorid, HARUN/0000-0001-8579-9939
dc.authoridIsik, Naciye/0000-0002-7444-5913
dc.authorwosidGunbey, HP/JAN-9081-2023
dc.authorwosidIsik, Naciye/HGF-1244-2022
dc.contributor.authorDemir, Harun
dc.contributor.authorDogan, Bedriye
dc.contributor.authorGunbey, Hediye Pinar
dc.contributor.authorIsik, Naciye
dc.contributor.authorYaprak, Gokhan
dc.date.accessioned2024-08-04T20:54:51Z
dc.date.available2024-08-04T20:54:51Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractackground: To evaluate the factors influencing brain metastases (BM) local control (LC) after stereotactic radiotherapy (SRT).Methods: Between 2010 and 2020, a cohort of 145 patients (246 BM) treated consecutively with robotic radiosurgery was analysed.Results: Median age was 61 years (range, 29-90 years). Median radiological follow-up of the lesions was 21.7 months (range, 3-115 months). The mean overall survival and LC were 33.0 and 82.7 months, respectively. On univariate analysis, sex, primary cancer site, histological type, use of systemic steroids, maximum diameter, volume, early MRI response, isodose line, number of fractions, BED10 value, and BED10 value proportional to volume and maximum diameter were significant factors for LC. On multivariate analysis, female sex (hazard ratio [HR]: 2.10 P: 0.035), adenocarcinoma histology (HR: 6.54 P: 0.001), no steroid use (HR: 3.60 P: 0.001), maximum diameter (<= 1 cm) (HR: 2.64 P: 0.018), complete response of lesion at first follow-up MRI compared to stable or progressive disease (HR: 4.20, P = 0.024; HR: 19.15, P < 0.001), isodose line (>= 90%) (HR: 2.00 P: 0.036), and tumour volume (PTV <= 2 cc) (HR: 5.19 P: 0.001) were independent factors improving LC.Conclusions: SRT is an effective treatment for patients with a limited number of BM with a high LC rate. There are many factors related to the patient, tumour, and radiotherapy plan that have an impact on LC after SRT in brain metastases. These results warrant further investigation in a prospective setting.en_US
dc.identifier.doi10.1111/ans.18786
dc.identifier.endpage839en_US
dc.identifier.issn1445-1433
dc.identifier.issn1445-2197
dc.identifier.issue5en_US
dc.identifier.pmid37984534en_US
dc.identifier.scopus2-s2.0-85177207250en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage833en_US
dc.identifier.urihttps://doi.org/10.1111/ans.18786
dc.identifier.urihttps://hdl.handle.net/11616/101679
dc.identifier.volume94en_US
dc.identifier.wosWOS:001107397900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnz Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbrain metastasisen_US
dc.subjectlocal controlen_US
dc.subjectstereotactic radiotherapyen_US
dc.titlePredictors of local control after robotic stereotactic radiotherapy for brain metastases: 10-years-experience after Cyberknife installationen_US
dc.typeArticleen_US

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