Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats

Basit Öğe Kaydı
dc.contributor.authorKalkan, Ferhat
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorDisli, Olcay M.
dc.contributor.authorTanriverdi, Lokman H.
dc.contributor.authorOzhan, Onural
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorCetin, Asli
dc.contributor.authorVardi, Nigar
dc.contributor.authorOtlu, Yilmaz O.
dc.contributor.authorAcet, Ahmet
dc.date.accessioned2019-07-24T12:55:53Z
dc.date.available2019-07-24T12:55:53Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24h; group III (DEX+ISO): DEX (250mg/kg) was applied 30min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO2), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO2 values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, whereas DEX treatment significantly reduced these parameters. Also, ISO-induced morphological alterations such as disorganization of cardiomyocytes, loss of myofibrils and cytoplasmic vacuolization whereas these histological damages were significantly decreased in ISO+DEX and DEX+ISO groups when compared to the ISO group. This study implies the cardioprotective effects of DEX on ISO-induced cardiotoxicity.en_US
dc.identifier.citationKalkan, F. Parlakpinar, H. Disli, OM. Tanriverdi, LH. Ozhan, O. Polat, A. Cetin, A. Vardi, N. Otlu, YO. Acet, A. (2018). Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats. Cilt:119 Sayı:9, 7479-7489 ss.en_US
dc.identifier.doi10.1002/jcb.27058en_US
dc.identifier.endpage7489en_US
dc.identifier.issue9en_US
dc.identifier.startpage7479en_US
dc.identifier.urihttps://hdl.handle.net/11616/12912
dc.identifier.volume119en_US
dc.language.isoenen_US
dc.publisherWILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USAen_US
dc.relation.ispartofJournal of cellular bıochemıstryen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectcardiotoxicityen_US
dc.subjectdexpanthenolen_US
dc.subjecthearten_US
dc.subjectisoproterenolen_US
dc.subjectoxidative stressen_US
dc.titleProtective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in ratsen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Fizyoloji Anabilim Dalı Koleksiyonu