The levels of cytokines and nitric oxide in rabbit vitreous humor after retinal laser photocoagulation

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.contributor.authorEr, H
dc.contributor.authorDoganay, S
dc.contributor.authorTurkoz, Y
dc.contributor.authorCekmen, M
dc.contributor.authorDaglioglu, MC
dc.contributor.authorGunduz, A
dc.contributor.authorEvereklioglu, C
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: To determine the levels of nitric oxide (NO) and cytokines such as interleukin 1-beta (IL-1 beta), interleukin G (IL-6), interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) on vitreous humor following retinal laser photocoagulation. MATERIALS AND METHODS: The rabbits were divided into 3 groups of 4 animals (8 eyes) each. Twelve pigmented rabbit eyes underwent modified grid pattern photocoagulation with a power of 240 mW (group I); 300 mW (group II); and 360 mW (group III). The eyes received 200 burns using a spot size of 200 mu, and duration of 0.2 s. Vitreous humor samples were collected from each eye preoperatively and at 24 and 72 hours after the laser. RESULTS: When compared to preoperative levels, IL-6 levels were increased in all groups; IL-1 beta levels were increased significantly only in group III. IL-8 levels were high in groups II and III only at 72 hours (P <0.05). TNF levels were elevated significantly in group II and III only at 24 hours (P <0.05). NO levels were significantly higher than preoperative values in all groups at all times. CONCLUSION: Our results support that especially IL-6, IL-8, and NO levels increase significantly following laser photocogulation. This preliminary study suggests that IL-6, IL-8, and NO might be dominant contributing factors in the occurrence of the inflammation postoperatively.en_US
dc.identifier.endpage483en_US
dc.identifier.issn0022-023X
dc.identifier.issue6en_US
dc.identifier.pmid11095125en_US
dc.identifier.scopus2-s2.0-0033750604en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://hdl.handle.net/11616/93217
dc.identifier.volume31en_US
dc.identifier.wosWOS:000165263600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSlack Incen_US
dc.relation.ispartofOphthalmic Surgery and Lasersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrowth-Factor-Betaen_US
dc.subjectTransforming Growth-Factor-Beta-2en_US
dc.subjectProliferative Vitreoretinopathyen_US
dc.subjectInterleukin-6en_US
dc.subjectSecretionen_US
dc.subjectSynthaseen_US
dc.subjectKryptonen_US
dc.subjectCellsen_US
dc.subjectArgonen_US
dc.subjectRaten_US
dc.titleThe levels of cytokines and nitric oxide in rabbit vitreous humor after retinal laser photocoagulationen_US
dc.typeArticleen_US

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