Effects of central FGF21 infusion on the glucose homeostasis in rats (brain-pancreas axis)

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dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidYilmaz, Umit/JFA-5784-2023
dc.contributor.authorTanbek, Kevser
dc.contributor.authorYilmaz, Umit
dc.contributor.authorGul, Mehmet
dc.contributor.authorKoc, Ahmet
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:53:22Z
dc.date.available2024-08-04T20:53:22Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroductionGlucose homeostasis is a physiological process mediated by a variety of hormones. Fibroblast growth factor (FGF) 21 is a protein expressed in the liver, adipose tissue, muscle and pancreas and exerts actions in multiple targets including adipose, liver, pancreas and hypothalamus. The aim of this study was to examine the possible involvement of FGF21 in pancreatic and central control of glucose by measuring reflective changes in the release of insulin and glucagon.MethodsThirty adult male Wistar Albino rats were divided; Control, PD + aCSF, PD + FGF21 groups (n = 10). Effects of intracerebroventricular (icv) FGF21 administration to pancreatic denervated (PD) rats. Agouti-related protein (AgRP), Pro-opiomelanocortin (POMC) levels and blood glucose homeostasis were investigated.ResultsAdministration of FGF21 to 3rd ventricle increased food consumption but body weight didn't change significantly. AgRP level increased, pancreatic insulin levels increased, and glucagon level decreased.ConclusionCentral FGF21 administration is effective in regulating blood glucose homeostasis by increasing the amount and efficiency of insulin and changing glucose use.en_US
dc.description.sponsorshipResearch Support Unit of Inonu University [TSA-2018/1489]en_US
dc.description.sponsorshipThis work was supported by The Research Support Unit of Inonu University (Project Number TSA-2018/1489).en_US
dc.identifier.doi10.1080/13813455.2023.2166964
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.pmid36645396en_US
dc.identifier.scopus2-s2.0-85146344658en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2023.2166964
dc.identifier.urihttps://hdl.handle.net/11616/101120
dc.identifier.wosWOS:000913132000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlucose homeostasisen_US
dc.subjectFGF21en_US
dc.subjectinsulinen_US
dc.subjectglucagonen_US
dc.subjectpancreatic denervationen_US
dc.subjectAgRPen_US
dc.subjectPOMCen_US
dc.titleEffects of central FGF21 infusion on the glucose homeostasis in rats (brain-pancreas axis)en_US
dc.typeArticleen_US

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