Relationship between serum homocysteine levels and structural-functional carotid arterial abnormalities in inactive Behcet's disease

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dc.authoridAkaycan, Jülide/0000-0002-9174-6777
dc.authoridPekdemir, Hasan/0000-0002-4913-5120
dc.authoridARSLAN, Ahmet Kadir/0000-0001-8626-9542
dc.authoridCansel, Mehmet/0000-0003-4740-4371;
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.authorwosidARSLAN, Ahmet Kadir/AAA-2409-2020
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidErmis, Necip/A-5184-2018
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorYagmur, Julide
dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorCansel, Mehmet
dc.contributor.authorKarincaoglu, Yelda
dc.contributor.authorErmis, Necip
dc.contributor.authorPekdemir, Hasan
dc.date.accessioned2024-08-04T20:44:17Z
dc.date.available2024-08-04T20:44:17Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Behcet's disease (BD) is a chronic autoimmune disorder with symptoms manifesting from an underlying vasculitis. Since the disease activity is correlated with characteristic vascular endothelial dysfunction, BD places individuals at increased risk of cardiovascular diseases, such as atherosclerosis. Hyperhomocysteinaemia is an independent risk factor for arteriosclerotic vascular diseases. Aim: This study was designed to investigate how plasma homocysteine (Hcy) affects the structural and functional properties of the carotid artery in humans. Methods: Sixty-eight BD patients with subclinical atherosclerosis and 40 healthy controls underwent carotid sonography and Doppler ultrasound to measure carotid artery intima-media thickness (C-IMT) and carotid stiffness and distensibility (indicating elasticity). Total Hcy level was determined by enzyme-linked immunosorbent assay. For analysis, the BD patients were sub-grouped according to hyperhomocysteinaemia (>15 mu mol/L). Results: The patients with BD were found to have increased C-IMT and beta stiffness and decreased distensibility. In addition, hyperhomocysteinaemia was significantly correlated with these detrimental changes in the carotid artery, possibly raising the risk of these patients developing atherosclerosis. Conclusions: These findings suggest a potential mechanism of atherosclerosis in BD and highlight the processes that future research should focus on to address identification and prophylactic treatment of BD patients at risk of cardiovascular disease.en_US
dc.identifier.doi10.5603/KP.a2017.0227
dc.identifier.endpage417en_US
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue2en_US
dc.identifier.pmid29192953en_US
dc.identifier.scopus2-s2.0-85042071260en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage413en_US
dc.identifier.urihttps://doi.org/10.5603/KP.a2017.0227
dc.identifier.urihttps://hdl.handle.net/11616/98157
dc.identifier.volume76en_US
dc.identifier.wosWOS:000425965300016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectarterial distensibilityen_US
dc.subjecthomocysteineen_US
dc.titleRelationship between serum homocysteine levels and structural-functional carotid arterial abnormalities in inactive Behcet's diseaseen_US
dc.typeArticleen_US

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