Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study

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dc.authoridSAYGILI, Emre Sedar/0000-0003-0022-5704
dc.authoridAgbaht, Kemal/0000-0003-3122-5491
dc.authoridÖZER, ÖZGE/0000-0003-1795-329X
dc.authoridKorkmaz, Fatma Nur Nur/0000-0002-3994-8320
dc.authoridSener, Selcuk Yusuf/0000-0003-1340-0997
dc.authoridKirac, Cem/0000-0002-0249-9867
dc.authoridBahcecioglu, Adile Begum/0000-0003-0777-8934
dc.authorwosidSAYGILI, Emre Sedar/K-8579-2019
dc.authorwosidAgbaht, Kemal/AAV-3125-2021
dc.authorwosidEMUR GUNAY, YASEMIN/JEO-9371-2023
dc.authorwosidAydemir, Mustafa/ABB-7947-2020
dc.authorwosidTekin, Sakin/HJP-0599-2023
dc.authorwosidÖZER, ÖZGE/AEZ-4250-2022
dc.authorwosidKorkmaz, Fatma Nur Nur/IZP-6196-2023
dc.contributor.authorBatman, Adnan
dc.contributor.authorYazici, Dilek
dc.contributor.authorDikbas, Oguz
dc.contributor.authorAgbaht, Kemal
dc.contributor.authorSaygili, Emre Sedar
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorBursa, Nurbanu
dc.date.accessioned2024-08-04T20:54:41Z
dc.date.available2024-08-04T20:54:41Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractContext The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. Methods This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19-related SAT (Cov-SAT), SARS-CoV-2 vaccine-related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. Results Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. Conclusion Since there is no difference in terms of follow-up parameters and outcomes, COVID-19- and SARS-CoV-2 vaccine-related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.en_US
dc.identifier.doi10.1210/clinem/dgad235
dc.identifier.endpageE1026en_US
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.issue10en_US
dc.identifier.pmid37186260en_US
dc.identifier.scopus2-s2.0-85171601419en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE1013en_US
dc.identifier.urihttps://doi.org/10.1210/clinem/dgad235
dc.identifier.urihttps://hdl.handle.net/11616/101577
dc.identifier.volume108en_US
dc.identifier.wosWOS:000999236300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEndocrine Socen_US
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsubacute thyroiditisen_US
dc.subjectSARS-CoV-2 vaccineen_US
dc.subjectCOVID-19en_US
dc.titleSubacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Studyen_US
dc.typeArticleen_US

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