Potent protective effect of apricot and ?-carotene on methotrexate-induced intestinal oxidative damage in rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidERDOĞAN, Ali/ABG-8548-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorOzturk, Feral
dc.contributor.authorAtes, Burhan
dc.contributor.authorGul, Mehmet
dc.contributor.authorCetin, Asli
dc.contributor.authorErdogan, Ali
dc.date.accessioned2024-08-04T20:30:57Z
dc.date.available2024-08-04T20:30:57Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSeveral studies have well confirmed the contribution of oxidative stress in the pathogenesis of methotrexate (MTX)-induced damage in the small intestine. Many agents have been tried experimentally to reduce or inhibit the oxidative stress. To our knowledge, there is no study about apricot consumption on the MTX-induced damage in the small intestine. The aim of this study was to determine the possible protective effects of apricot and beta-carotene on MTX-induced intestinal damage in rats. The rats were randomly divided into seven groups as follows; I-control group; H-apricot group; III-beta-carotene group; IV-MTX group: V-apricot + MTX group; VI-beta-carotene + MTX group and VII-apricot + beta-carotene + MTX group. In the MTX group; fusion and shortening in the villus, epithelial desquamation, crypt loss, inflammatory cell infiltration in the lamina propria, goblet cell depletion and microvillar damage were observed in the small intestine. Parallel to histological results, malondialdehyde (MDA) content and myeloperoxidase (MPO) activity were found to be increased, whereas superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GP-x) activities and glutathione (GSH) content were decreased in the MTX group. However, single or combined application of apricot and p-carotene ameliorated all of these hazordous effects in antioxidant system in MTX-treated groups. In conclusion, our results demonstrate that apricot and/or beta-carotene treatment may protect the impairment of oxidative stress and ameliorate MTX-induced intestine damage at biochemical and histological levels. (C) 2008 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University [2005/78]; Apricot Research Foundation of Malatya Provinceen_US
dc.description.sponsorshipThis study was supported by a Grant from Scientific Research Fund of Inonu University (Project number: 2005/78) and Apricot Research Foundation of Malatya Province. The apricot which used in this Study was obtained from Karapinar Kirlangic Koyleri Tarimsal Kalkinma Kooperatifi Akcadag/Malatya/TURKEY. The apricot was minced for feeding in Toska Tanm Urunleri Ticaret Sanayi Limited Dilek/Malatya/TURKEY.en_US
dc.identifier.doi10.1016/j.fct.2008.05.039
dc.identifier.endpage3022en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue9en_US
dc.identifier.pmid18601970en_US
dc.identifier.scopus2-s2.0-50249176999en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3015en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2008.05.039
dc.identifier.urihttps://hdl.handle.net/11616/94636
dc.identifier.volume46en_US
dc.identifier.wosWOS:000259762100008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapricoten_US
dc.subjectbeta-caroteneen_US
dc.subjectoxidative damageen_US
dc.subjectmethotrexateen_US
dc.titlePotent protective effect of apricot and ?-carotene on methotrexate-induced intestinal oxidative damage in ratsen_US
dc.typeArticleen_US

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