Surgical site infection and risk factors following right lobe living donor liver transplantation in adults: A single-center prospective cohort study

dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authoridGunes, Orgun/0000-0002-0576-6086
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridUylas, Ufuk/0000-0003-4195-5498
dc.authoridAktas, Aydin/0000-0003-3407-0210
dc.authoridKose, Adem/0000-0002-1853-1243
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.authorwosidGunes, Orgun/GLN-4395-2022
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidUylas, Ufuk/A-1827-2019
dc.authorwosidAktas, Aydin/AAC-3425-2021
dc.authorwosidKose, Adem/AAD-1226-2020
dc.contributor.authorAktas, Aydin
dc.contributor.authorKayaalp, Cuneyt
dc.contributor.authorGunes, Orgun
dc.contributor.authorGokler, Cihan
dc.contributor.authorUylas, Ufuk
dc.contributor.authorCicek, Egemen
dc.contributor.authorErsoy, Yasemin
dc.date.accessioned2024-08-04T20:46:50Z
dc.date.available2024-08-04T20:46:50Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction Surgical site infection (SSI) is an important cause of decreased graft survival, prolonged hospital stay, and higher costs following living donor liver transplantation. There are several risk factors for SSI. In this cohort study, we aimed to investigate the incidence of SSI at our center and the associated risk factors. Materials and Methods Adult right lobe living donor liver transplantations were included in this prospective cohort. Patients who died postoperatively within 3 days; patients with infected ascites or open abdomen, cadaveric, or pediatric transplants; and patients with biologic or cryopreserved vascular grafts were excluded. Patients' demographic characteristics and perioperative surgical findings were recorded. SSI follow-up was continued for 90 days. CDC-2017 criteria were used to diagnose SSI. In the presence of superficial, deep, and organ/space SSI, only the organ in the poorest condition was included in SSI evaluation. The patients were administered similar to antibiotic prophylaxes and immunosuppressive protocols. Results A total of 101 patients were enrolled in this study, of which 30 (29.7%) were diagnosed with SSI. Organ/space, only deep, and only superficial SSI were noted in 90% (27/30), 6.7% (2/30), and 3.3% (1/30) of the patients, respectively. Twenty-five of 30 patients with SSI had a remote site infection. One or more bacteria observed in cultures were obtained from 28 patients. A donor-recipient age difference of >10 years, cold ischemia lasting for >= 150 minutes, surgical duration of >= 600 minutes, intraoperative hemorrhage of >= 1000 mL, intraoperative blood transfusion, biliary leak or stricture, prolonged mechanical ventilation, prolonged intensive care unit and hospital stay, remote site infection, and the need for reoperation were associated with increased SSI incidence. Preoperative and intraoperative levels of blood glucose, albumin, and hemoglobin were not associated with SSI. A donor-recipient age difference of >10 years, remote site infection, and biliary leak were found to be independent risk factors for SSI. Hospital mortality with and without SSIs was 6.7% vs 4.4%, P = .61. Discussion Organ/space SSIs were the essential part of SSIs following right lobe living donor liver transplantations. Donor-recipient age gap, prolonged cold ischemia time, complicated surgery, and postoperative biliary complications were the main causes of SSIs. Although they did not increase the perioperative mortality, they promote increased rate of reoperations, remote infections, prolonged intensive care unit, and hospital stays.en_US
dc.identifier.doi10.1111/tid.13176
dc.identifier.issn1398-2273
dc.identifier.issn1399-3062
dc.identifier.issue6en_US
dc.identifier.pmid31539456en_US
dc.identifier.scopus2-s2.0-85073944846en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/tid.13176
dc.identifier.urihttps://hdl.handle.net/11616/98990
dc.identifier.volume21en_US
dc.identifier.wosWOS:000802156800031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofTransplant Infectious Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepaticen_US
dc.subjectinfectionen_US
dc.subjectprophylaxisen_US
dc.subjecttransplantationen_US
dc.subjectwounden_US
dc.titleSurgical site infection and risk factors following right lobe living donor liver transplantation in adults: A single-center prospective cohort studyen_US
dc.typeArticleen_US

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