Objective evaluation of the effects of intravenous lidocaine on tinnitus

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dc.authoridBayindir, Tuba/0000-0003-4150-5016
dc.authoridOZTURAN, ORHAN/0000-0002-6129-8627
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidOZTURAN, ORHAN/E-9610-2012
dc.authorwosidBayindir, Tuba/ABG-9517-2020
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.authorwosidOZTURAN, ORHAN/B-4984-2015
dc.contributor.authorKalcioglu, MT
dc.contributor.authorBayindir, T
dc.contributor.authorErdem, T
dc.contributor.authorOzturan, O
dc.date.accessioned2024-08-04T20:56:14Z
dc.date.available2024-08-04T20:56:14Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Tinnitus is one of the most common and distressing otological symptoms. Although numerous therapeutic modalities have been tried, there is no consensus regarding effective therapeutic agents up to now. The effects of lidocaine on tinnitus have been reported in literature using either subjective or audiologic tests. Nevertheless, the otoacoustic emissions (OAEs) have not been utilized to demonstrate lidocaine's effect on the cochlea in the English literature. The aim of this study was to evaluate the effect of lidocaine on tinnitus by considering the alterations with tinnitus, it induces on OAEs and subjective symptoms. Methods: This study was performed in 30 patients with tinnitus. Twenty-eight of the patients had normal hearing and two of them evidenced mild sensorineural hearing loss. To determine the severity of tinnitus, the patients were required to fill out a tinnitus scoring scale before lidocaine infusion on the same day. Then, lidocaine was administered intravenously to each patient at a dose of mg/kg body weight over a period of 30 min. Spontaneous otoacoustic emissions (SOAEs) and distortion product otoacoustic 1.5 mg emissions (DPOAEs) were measured three times; namely before lidocaine injection, at 25 min after injection and on the next day. The severity of tinnitus was scored again 1 d, 1 wk and 1 mo after lidocaine administration. Results: Immediately after infusion, four patients (13.3%) declared total suppression of tinnitus, whereas three patients (10%) reported only partial relief in tinnitus subjectively. The patients, who had a subjective improved response (group 1) were compared with the patients, who had no response (group 2). Statistically significant changes (p < 0.05) in DPOAE response/growth or input/output (I/O) functions were observed at 1, 2, 3, 4 and 6 kHz frequencies in lidocaine responders and at 1, 2, 3, 4 and 5 kHz frequencies in no responders at different primary stimulus levels. Statistically significant changes (p < 0.05) were seen at 2 kHz for 53 dB and at 3 kHz for 62 dB SPL primaries in both groups. When the significant results of these two groups were compared with each other, differences were found insignificant. Conclusion: Systematic OAE measurements revealed that no changes occurred in SOAE and DPOAE levels in that alterations disappeared the next day. Subjective relief from tinnitus was stated in some of the patients and lasted for 4 wk at longest. (C) 2004 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.heares.2004.08.004
dc.identifier.endpage88en_US
dc.identifier.issn0378-5955
dc.identifier.issn1878-5891
dc.identifier.issue1-2en_US
dc.identifier.pmid15574302en_US
dc.identifier.scopus2-s2.0-9644281169en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1016/j.heares.2004.08.004
dc.identifier.urihttps://hdl.handle.net/11616/102148
dc.identifier.volume199en_US
dc.identifier.wosWOS:000226174200008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofHearing Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttinnitusen_US
dc.subjectlidocaineen_US
dc.subjecttreatmenten_US
dc.subjectotoacoustic emissionsen_US
dc.titleObjective evaluation of the effects of intravenous lidocaine on tinnitusen_US
dc.typeArticleen_US

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