Anti-inflammatory Effects and Pharmacokinetics of Bupivacaine in Transversus Abdominis Plane Block for Living Liver Donors: A Prospective Randomized Clinical Trial

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dc.contributor.authorYalin, Mehmet Ridvan
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorUcar, Muharrem
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorColak, Yusuf Ziya
dc.contributor.authorOzdemir, Emine
dc.contributor.authorUgur, Yilmaz
dc.date.accessioned2026-04-04T13:34:46Z
dc.date.available2026-04-04T13:34:46Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective. Transversus abdominis plane (TAP) blocks have been reported to decrease postoperative pain and opioid use. Local anesthetics modulate the local and systemic inflammatory reaction. Our aim was to examine the effect of TAP block with bupivacaine on the antiinflammatory response in living liver donors. Methods. The randomized prospective clinical study was carried out on 72 living liver donors, aged 18 to 65 scheduled for right hepatectomy. TAP blocks were performed bilaterally with ultrasound guidance using 1.5 mg/kg of 0.5% bupivacaine for group 2. Group 1 patients were the control group. In both groups, blood samples were obtained preoperatively, 30 minutes and 2, 6, and 24 hours after the injection for cytokine measurement. In group 2, to examine the plasma bupivacaine level, blood samples were obtained preoperatively as well as 30 minutes and 1, 2, 6, 12, and 24 hours after injection. The primary outcome was to assess the effect of TAP block on the inflammatory response using cytokine levels. Results. No difference was observed between cytokine levels (tumor necrosis factor-alpha, interleukin [IL]-1 and IL-6) between groups Significant positive correlations were observed between the plasma bupivacaine concentration and IL-1 and IL-6 levels at 2, 6, and 24 hours. Conclusion. Although the TAP block did not affect the levels of cytokines significantly, a significant association was seen between the concentrations of plasma bupivacaine and the levels of IL-1 and IL-6 at 2, 6, and 24 hours. In contrast, the clinical significance of this association is still under investigation.
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [2018-911]
dc.description.sponsorshipThe authors provide financial support received financial support from Inonu University Scientific Research Projects Coordinatorship. Funding for the present study was supported by Inonu University Scientific Research Projects Coordination Unit with project number 2018-911 for drug supply with bupivacaine and cytokines analysis.
dc.identifier.doi10.1016/j.transproceed.2025.06.003
dc.identifier.endpage1103
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue6
dc.identifier.orcid0000-0002-9040-4249
dc.identifier.orcid0000-0002-8729-8705
dc.identifier.pmid40619334
dc.identifier.scopus2-s2.0-105009701050
dc.identifier.scopusqualityQ3
dc.identifier.startpage1095
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2025.06.003
dc.identifier.urihttps://hdl.handle.net/11616/109392
dc.identifier.volume57
dc.identifier.wosWOS:001542004100016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectPlasma Ropivacaine Concentrations
dc.subjectLocal-Anesthetics
dc.subjectInflammatory Response
dc.subjectPostoperative Pain
dc.subjectLidocaine
dc.subjectReconstruction
dc.subjectInterleukin-6
dc.subjectAnalgesia
dc.subjectSurgery
dc.subjectGraft
dc.titleAnti-inflammatory Effects and Pharmacokinetics of Bupivacaine in Transversus Abdominis Plane Block for Living Liver Donors: A Prospective Randomized Clinical Trial
dc.typeArticle

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