Investigation of the cardiotoxic effects of parenteral nutrition in rabbits

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dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridKaraca, Yücel/0000-0002-5184-5308
dc.authoridTaşçı, Aytaç/0000-0002-4024-5219
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidKaraca, Yücel/AAA-4477-2022
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.contributor.authorGurunluoglu, Kubilay
dc.contributor.authorGul, Mehmet
dc.contributor.authorKocbiyik, Alper
dc.contributor.authorKoc, Ahmet
dc.contributor.authorUremis, Nuray
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-08-04T20:45:59Z
dc.date.available2024-08-04T20:45:59Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Parenteral nutrition (PN) is used for the intravenous delivery of nutrients to patients who cannot take food orally. However, it is not clear whether PN also negatively impacts cardiac tissue. The present empirical study investigated the cardiac effects of PN in rabbits. Methods: The effects of PN were examined in three groups of rabbits: animals in the PN + fasting group (n = 14) had been fully fasted before receiving a full PN dose via an intravenous central catheter; the PN + oral feeding group (n = 14) received half of the daily calorie requirement as a half dose of PN via an intravenous central catheter; the third group consisted of controls (n = 14) with full enteral feeding and full enteral fluid intake with no PN and no central venous catheter. Al the end of the 10-day study period, the rabbits were subjected to echocardiographic examination and euthanized. Blood and tissue samples were obtained from all groups. DNA was isolated from nucleated blood cells. Tissue samples were examined by both light and electron microscopy, relative telomere length was determined from DNA, and blood samples were analyzed biochemically. Results: At the end of the study, there were no statistically significant differences in weight change between the three groups. Echocardiography revealed minimally impaired diastolic function in the PN + fasting group compared to the other groups. Biochemical and histopathological analyses, relative telomere length determination, and electron micrographs showed significant cardiac damage in the PN + fasting group but not in the PN + oral feeding group or the control group. The blood biochemical analyses showed hyperglycemia and a low insulin level in the PN + fasting group but not in the other two groups. Conclusions: A combination of PN and fasting may damage the cardiac muscle cells of rabbits via a mechanism involving hyperglycemia and oxidative stress. Additional enteral feeding may protect against the destructive effects of PN on cardiac tissue. (C) 2019 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [TSA-2018-1023]en_US
dc.description.sponsorshipThis project was supported financially by Inonu University Scientific Research Projects Coordination Unit by TSA-2018-1023 project code.en_US
dc.identifier.doi10.1016/j.jpedsurg.2019.04.027
dc.identifier.endpage474en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue3en_US
dc.identifier.pmid31109733en_US
dc.identifier.scopus2-s2.0-85065768163en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2019.04.027
dc.identifier.urihttps://hdl.handle.net/11616/98799
dc.identifier.volume55en_US
dc.identifier.wosWOS:000522662800020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParenteral nutritionen_US
dc.subjectCardiotoxicityen_US
dc.subjectHyperglycemiaen_US
dc.subjectOxidative stressen_US
dc.titleInvestigation of the cardiotoxic effects of parenteral nutrition in rabbitsen_US
dc.typeArticleen_US

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