The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin

Basit Öğe Kaydı
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridKIZILAY, Ahmet/0000-0003-3048-6489
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridsapmaz, emrah/0000-0002-0346-8704
dc.authoridtoplu, yuksel/0000-0002-5444-557X
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidKIZILAY, Ahmet/ABI-8293-2020
dc.authorwosidToplu, Yuksel/AAA-3133-2021
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorToplu, Yuksel
dc.contributor.authorSapmaz, Emrah
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorKelles, Mehmet
dc.contributor.authorKalcioglu, M. Tayyar
dc.contributor.authorTanbek, Kevser
dc.contributor.authorKizilay, Ahmet
dc.date.accessioned2024-08-04T20:41:36Z
dc.date.available2024-08-04T20:41:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P <0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group's measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.en_US
dc.identifier.doi10.21053/ceo.2016.9.1.14
dc.identifier.endpage20en_US
dc.identifier.issn1976-8710
dc.identifier.issn2005-0720
dc.identifier.issue1en_US
dc.identifier.pmid26976021en_US
dc.identifier.scopus2-s2.0-84960445390en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://doi.org/10.21053/ceo.2016.9.1.14
dc.identifier.urihttps://hdl.handle.net/11616/97222
dc.identifier.volume9en_US
dc.identifier.wosWOS:000372773000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Otorhinolaryngolen_US
dc.relation.ispartofClinical and Experimental Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectOtotoxicityen_US
dc.subjectDexpanthenolen_US
dc.subjectOtoacoustic Emissionsen_US
dc.subjectBiomarkersen_US
dc.titleThe Effect of Dexpanthenol on Ototoxicity Induced by Cisplatinen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu