Serum ghrelin levels in children with primary protein-energy malnutrition

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dc.contributor.authorAltinkaynak, Sevin
dc.contributor.authorSelimoglu, Mukadder A.
dc.contributor.authorErtekin, Vildan
dc.contributor.authorKilicarslan, Buket
dc.date.accessioned2024-08-04T20:30:57Z
dc.date.available2024-08-04T20:30:57Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Ghrelin, an appetite-stimulating peptide, increases in cachectic conditions. It probably reflects peripheral nutritional status and influences nutrient intake and growth. The aim of the present study was to determine serum ghrelin levels in children with primary protein-energy malnutrition (PEM) and to find if any correlation exists between serum ghrelin levels and the clinical presentation of those patients. Methods: Twenty-eight children with primary PEM and 10 healthy children were included. Serum fasting ghrelin levels were measured using radioimmunoassay. Results: Mean serum ghrelin level of healthy children and those with PEM were 107.7 +/- 40.1 pg/mL and 141.6 +/- 123.8 pg/mL, respectively (P < 0.001). Ghrelin levels were independent of age and sex (P > 0.05). Ghrelin was negatively correlated with body mass index in healthy children (P < 0.01), but not in those with PEM (P > 0.05). Mean serum ghrelin level of children with moderate malnutrition was higher than that of children with severe malnutrition (199.2 +/- 154.1 pg/mL vs 98.4 +/- 74.3 pg/mL, P < 0.05). Mean serum ghrelin levels of patients with kwashiorkor, marasmic kwashiorkor, and marasmus were 127.9 +/- 97.8 pg/mL, 138.7 +/- 95.8 pg/mL, and 162.3 +/- 185.0 pg/mL, respectively (P > 0.05). Conclusion: Serum ghrelin level is higher in patients with PEM, especially in those with marasmus, compared to healthy children. Although this observation suggests that ghrelin helps to fight malnutrition in children, it is obvious that further studies are needed to clarify the exact pathogenetic mechanism regarding this condition.en_US
dc.identifier.doi10.1111/j.1442-200X.2008.02606.x
dc.identifier.endpage431en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue4en_US
dc.identifier.pmid18937750en_US
dc.identifier.scopus2-s2.0-50249181683en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-200X.2008.02606.x
dc.identifier.urihttps://hdl.handle.net/11616/94637
dc.identifier.volume50en_US
dc.identifier.wosWOS:000258732300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectghrelinen_US
dc.subjectkwashiorkoren_US
dc.subjectmarasmusen_US
dc.subjectprotein-energy malnutritionen_US
dc.titleSerum ghrelin levels in children with primary protein-energy malnutritionen_US
dc.typeArticleen_US

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