The mean platelet volume levels in children with PFAPA syndrome

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dc.authoridTekin, Mehmet/0000-0002-1157-1314;
dc.authorwosidTekin, Mehmet/ABG-8307-2020
dc.authorwosidToplu, Yuksel/AAA-3133-2021
dc.contributor.authorTekin, Mehmet
dc.contributor.authorToplu, Yuksel
dc.contributor.authorKahramaner, Zelal
dc.contributor.authorErdemir, Aydin
dc.contributor.authorGulyuz, Abdulgani
dc.contributor.authorKonca, Capan
dc.contributor.authorUckardes, Fatih
dc.date.accessioned2024-08-04T20:39:39Z
dc.date.available2024-08-04T20:39:39Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives:. To assess whether mean platelet volume (MPV) can be used as a marker in the differential diagnosis of periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome. Methods: The leucocyte counts, thrombocyte counts, and MPV values of 57 children with PFAPA syndrome were recorded during an attack and an attack free period. These values were compared with a healthy control group of 55 individuals. Demographic features of the PFAPA patients group including age, gender and age of first attack, age at diagnosis, frequency of attacks, serum reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were also recorded. Results: The MPV values of the children with PFAPA both during an attack and attack free period were found significantly lower than the MPV values of healthy control group (p < 0.001). Also, the MPV values of the children with PFAPA during an attack were significantly lower than in attack free periods (p < 0.001). The MPV values showed no correlation with leucocytes counts, CRP, and ESR during attacks. A 8.30 fl [area under the curve (AUC: 0.965)] optimal cutoff value of MPV with a sensitivity of 89.5% and specificity of 92.8% was determined during an attack in children with PFAPA. Conclusions: The MPV values during an attack and attack free period of patients with PFAPA is lower than in controls. The MPV values may be used as a marker in the differential diagnosis of PFAPA syndrome but more studies are needed and they should be prospective in order to validate this data. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2014.02.027
dc.identifier.endpage853en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue5en_US
dc.identifier.pmid24656227en_US
dc.identifier.scopus2-s2.0-84898543621en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage850en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2014.02.027
dc.identifier.urihttps://hdl.handle.net/11616/96408
dc.identifier.volume78en_US
dc.identifier.wosWOS:000336117900025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPFAPA syndromeen_US
dc.subjectMean platelet volumeen_US
dc.subjectErythrocyte sedimentation rateen_US
dc.subjectLeucocytosisen_US
dc.subjectSerum reactive proteinen_US
dc.titleThe mean platelet volume levels in children with PFAPA syndromeen_US
dc.typeArticleen_US

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