The genotoxicity of Tenofovir disoproxil fumarate in HBV-infected patients

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dc.contributor.authorYüksel, Şengül
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorKorkmaz, Selcen
dc.date.accessioned2024-08-04T19:53:16Z
dc.date.available2024-08-04T19:53:16Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTenofovir disoproxil fumarate (TDF) is an acyclic nucleotide reverse transcriptase inhibitor used as antiviral therapeutic drug in hepatitis B virus (HBV) infection treatment. We investigated whether HBV itself or TDF could enhance genotoxicity in HBV infected patients. A total of 30 HBV-infected patients were included in this study: 10 were untreated, 10 took therapy for 6 months, 10 took therapy for 12 months and a further 15 were control group. We used the micronucleus test (MN) and mitotic index (MI) to assess the genotoxic effects of TDF. MN and MI frequency were significantly increased in all the HBV-infected patient groups when compared to control. However, significant differences were not found between different time points within the therapy groups. The current data indicate that chronic HBV infection without treatment has an effect on MN and MI. TDF administration at therapeutic doses for 12 months also did not reduce the MI and MN, suggesting its protective action against HBV induced genotoxic damage. Larger-scale and longtime studies are required for a better understanding of the genotoxicity of TDF.en_US
dc.identifier.doi10.5455/medscience.2018.07.8829
dc.identifier.endpage603en_US
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage600en_US
dc.identifier.trdizinid307497en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2018.07.8829
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/307497
dc.identifier.urihttps://hdl.handle.net/11616/89636
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe genotoxicity of Tenofovir disoproxil fumarate in HBV-infected patientsen_US
dc.typeArticleen_US

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