Lipid Peroxidation and Antioxidant Enzyme Activities in Cancerous Bladder Tissue and Their Relation with Bacterial Infection: A Controlled Clinical Study

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dc.authorwosidkılıç, süleyman/AAO-2348-2020
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorKilic, Suleyman
dc.contributor.authorBayraktar, Mehmet Refik
dc.contributor.authorAksoy, Nurten
dc.date.accessioned2024-08-04T20:32:16Z
dc.date.available2024-08-04T20:32:16Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt is well known that antioxidants and reactive oxygen species play an important role in carcinogenesis. In this sudy, we attempted to evaluate antioxidant enzyme activities and lipid peroxidation levels in cancerous bladder tissue and to determine their relationship with bacterial infection. Bacterial culture was made from all urine samples using Blood and Eosin Methylene Blue agars for checking the presence of bacterial infections. We measured thiobarbituric acid reactive substances (TBARs) and activities of xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and catalase (CAT) in cancerous tissues of 25 bladder cancer patients, in noncancerous adjacent bladder tissues of 13 out of these 25 patients, and in control bladder tissues of 15 patients with a non-neoplastic genitourinary disease. TBARs levels increased and XO, SOD, GSH-PX, and CAT activities decreased significantly in cancerous bladder tissues. TBARS, XO, and SOD levels were not significantly different between noncancerous adjacent tissue and control bladder tissue. Statistically significantly lower GSH-PX and higher CAT activities were observed in noncancerous adjacent bladder tissue compared with cancerous tissue. GSH-PX level of tumor tissue was correlated significantly with tumor grade (r = -0.425, P = 0.034). Results suggested that pathway activity of free radicals were accelerated in the cancerous human bladder tissues via increased TBARs levels and decreased enzyme activities of XO, SOD, GSH-PX, and CAT, which implicated a severe exposure of cancerous tissues to oxidative stress. J. Clin. Lab. Anal. 24:25-30, 2010. (C) 2010 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/jcla.20356
dc.identifier.endpage30en_US
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue1en_US
dc.identifier.pmid20087949en_US
dc.identifier.scopus2-s2.0-75749084447en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.20356
dc.identifier.urihttps://hdl.handle.net/11616/94964
dc.identifier.volume24en_US
dc.identifier.wosWOS:000274403200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbladder canceren_US
dc.subjectxanthine oxidaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectcatalaseen_US
dc.subjectthiobarbituric acid reactive substancesen_US
dc.titleLipid Peroxidation and Antioxidant Enzyme Activities in Cancerous Bladder Tissue and Their Relation with Bacterial Infection: A Controlled Clinical Studyen_US
dc.typeArticleen_US

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