The role of protein oxidation in the development of diabetic microvascular complications

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dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridArslan, Yusuf/0000-0002-7621-6671
dc.authoridarslan, yusuf kemal/0000-0003-1308-8569
dc.authoridMertoglu, Cuma/0000-0003-3497-4092
dc.authorwosidEREL, Ozcan/U-1008-2019
dc.authorwosidArslan, Yusuf/HJH-6539-2023
dc.authorwosidarslan, yusuf kemal/GRR-4381-2022
dc.authorwosidMertoglu, Cuma/A-3506-2017
dc.contributor.authorMertoglu, Cuma
dc.contributor.authorSiranli, Gulsah
dc.contributor.authorCoban, T. Abdulkadir
dc.contributor.authorKarakurt, Yucel
dc.contributor.authorErsoy, Alevtina
dc.contributor.authorOzcicek, Adalet
dc.contributor.authorArslan, Yusuf
dc.date.accessioned2024-08-04T20:10:34Z
dc.date.available2024-08-04T20:10:34Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.en_US
dc.identifier.doi10.14744/nci.2021.33341
dc.identifier.endpage506en_US
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue5en_US
dc.identifier.pmid34909589en_US
dc.identifier.startpage500en_US
dc.identifier.trdizinid508452en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2021.33341
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/508452
dc.identifier.urihttps://hdl.handle.net/11616/92869
dc.identifier.volume8en_US
dc.identifier.wosWOS:000714065600010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectmicrovascular complicationsen_US
dc.subjectneuropathyen_US
dc.subjectretinopathyen_US
dc.subjectthiol-disulfideen_US
dc.titleThe role of protein oxidation in the development of diabetic microvascular complicationsen_US
dc.typeArticleen_US

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