Effects of Tolterodine and Trospium Chloride on Renal Damage Induced by Partial Upper Urinary Tract Obstruction

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186;
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidKarabulut, Ismail/A-5650-2016
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.contributor.authorKaraman, Abdurrahman
dc.contributor.authorSamdanci, Emine
dc.contributor.authorSayin, Sadegul
dc.contributor.authorKarabulut, Ismail
dc.contributor.authorFadillioglu, Ersin
dc.date.accessioned2024-08-04T20:37:42Z
dc.date.available2024-08-04T20:37:42Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE To examine the efficacy of trospium chloride and tolterodine on the renal parenchymal inflammatory process and upper urinary dilation in rats with chronic partial upper urinary tract obstruction. MATERIALS AND METHODS A total of 32 rats were divided into 4 groups: group 1, control; group 2, obstruction; group 3, obstruction plus tolterodine; and group 4, obstruction plus trospium chloride. In all groups, except for group 1, partial upper urinary tract obstruction was induced by embedding the upper quarter of the right ureter into the psoas muscle for 14 days. At the end of the experiment, the rats were killed. The catalase, malondialdehyde, and protein carbonyl levels were determined in renal tissue. Tubular dilation and parenchymal inflammation were evaluated using hematoxylin-eosin staining. Smooth muscle actin and cytoglobin were examined with immunohistochemical staining. RESULTS The obstruction group demonstrated severe pelvic dilation and parenchymal inflammation and increased smooth muscle actin staining in the wall of upper urinary tract (P < .05). The treatment of the rats with tolterodine and trospium chloride markedly attenuated the inflammatory alterations and reduced tubular dilation. This treatment also reduced elevated oxidative stress product levels and restored the depleted renal antioxidant enzyme. CONCLUSION These findings imply that increased renal pelvic pressure can contribute to renal parenchymal injury in chronic pelvic upper urinary tract obstruction. Antimuscarinic medications such as tolterodine and trospium chloride exert renoprotective effects, probably by prevention of pelvic pressure increases. UROLOGY 82: 194-200, 2013. (C) 2013 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2013.01.030
dc.identifier.endpage200en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue1en_US
dc.identifier.pmid23453648en_US
dc.identifier.scopus2-s2.0-84879555408en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2013.01.030
dc.identifier.urihttps://hdl.handle.net/11616/96117
dc.identifier.volume82en_US
dc.identifier.wosWOS:000321036200051en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUreteropelvic Junction Obstructionen_US
dc.subjectUreteral Obstructionen_US
dc.subjectOveractive Bladderen_US
dc.subjectOxidative Stressen_US
dc.subjectPelvic Pressuresen_US
dc.subjectSmooth-Muscleen_US
dc.subjectOxybutyninen_US
dc.subjectHydronephrosisen_US
dc.subjectExpressionen_US
dc.subjectDiagnosisen_US
dc.titleEffects of Tolterodine and Trospium Chloride on Renal Damage Induced by Partial Upper Urinary Tract Obstructionen_US
dc.typeArticleen_US

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