The effects of chronic exposure to ethanol and cigarette smoke on the level of reduced glutathione and malondialdehyde in rat kidney

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dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridAkgoz, Muslum/0000-0001-5065-8087
dc.authoridSozmen, Mahmut/0000-0001-7976-4051
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridAkgoz, Muslum/0000-0001-5065-8087
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidAkgoz, Muslum/A-6234-2015
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidSozmen, Mahmut/JUU-6343-2023
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidAkgoz, Muslum/AAG-4598-2019
dc.contributor.authorCigremis, Y
dc.contributor.authorTurkoz, Y
dc.contributor.authorAkgoz, M
dc.contributor.authorSozmen, M
dc.date.accessioned2024-08-04T20:15:13Z
dc.date.available2024-08-04T20:15:13Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of chronic ethanol intake and cigarette smoke exposure on rat kidney. The animals were divided into four experimental groups: (1) the control group (C), (2) the ethanol group (E), (3) the cigarette smoke group (CS), and (4) the cigarette smoke plus ethanol group (CS+E). Apart from the control group, these were treated with ethanol and/or cigarette smoke for 6 months. The animals were killed and the kidneys removed to determine the levels of reduced glutathione (GSH) and malondialdehyde (MDA) and for histopathological analysis. The levels of GSH/g wet tissue were 1.58+/-0.09 mumol, 0.91+/-0.05 mumol, 1.14+/-0.06 mumol, and 0.82+/-0.04 mumol for C, E, CS, and CS+E, respectively. In groups of E, CS, and CS+E, the GSH values were significantly lower than that of group C animals (P<0.05). Although, we detected lower GSH levels in the CS+E than the CS group (P<0.05), a significant difference in GSH levels between CS+E and E was not observed. The levels of MDA/g wet tissue were 40.1+/-3.4 nmol, 71.4+/-2.8 nmol, 64.0+/-3.6 nmol, and 76.5+/-4.3 nmol, for C, E, CS and CS+E, respectively. In E, CS, and CS+E, the MDA values were significantly higher than in group C (P<0.05). The increase in MDA levels in CS+E were not significantly different from groups E or CS. Histopathological analysis of the kidney slices showed severe degeneration of the tissues. Advanced hydropic degeneration of kidney tubules was clearly observed in the CS group. In group E, advanced tubular and interstitial damage, mononuclear cell infiltration and tubular thyroidization were clearly visible. In group CS+E, an intense inflammatory cell infiltration was detected under the transitional epithelium. We conclude that chronic exposure to ethanol and cigarette smoke may cause an oxidative burst in rat kidney by increasing the formation of reactive oxygen species.en_US
dc.identifier.doi10.1007/s00240-004-0406-x
dc.identifier.endpage218en_US
dc.identifier.issn0300-5623
dc.identifier.issn1434-0879
dc.identifier.issue3en_US
dc.identifier.pmid15205856en_US
dc.identifier.scopus2-s2.0-3142749660en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-004-0406-x
dc.identifier.urihttps://hdl.handle.net/11616/94250
dc.identifier.volume32en_US
dc.identifier.wosWOS:000222082700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcigarette smokeen_US
dc.subjectethanolen_US
dc.subjectkidneyen_US
dc.subjectraten_US
dc.subjectGSHen_US
dc.subjectMDAen_US
dc.titleThe effects of chronic exposure to ethanol and cigarette smoke on the level of reduced glutathione and malondialdehyde in rat kidneyen_US
dc.typeArticleen_US

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