Effects of Quercetin and Chrysin on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induced Hepatotoxicity in Rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorCiftci, Osman
dc.contributor.authorVardi, Nigar
dc.contributor.authorOzdemir, Ilknur
dc.date.accessioned2024-08-04T20:37:26Z
dc.date.available2024-08-04T20:37:26Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of current study is to investigate the effects of the administration of chrysin (CH) and quercetin (Q) on rat liver in which oxidative and histological damage had been induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were randomly divided into six equal groups. TCDD was orally administered at the dose of 2 mu g/kg/week, and Q and CH were orally administered at the doses of 20 mg/kg day and 50 mg/kg/day, respectively, by gavages dissolved in corn oil. The liver samples to be analyzed for the determination of oxidative and histological alternations were taken from rats at 60 days. The results indicated that although 2,3,7,8-TCDD significantly induced (P <= 0.01) lipid peroxidation (increase of MDA levels), it positively affected oxidant/antioxidant system (a decline in the levels of GSH, CAT, GSH-Px, and CuZn-SOD) in rats significantly. The histological changes observed in the liver correlated with the biochemical findings. However, these effects of TCDD on oxidative and histological changes were eliminated by Q and CH treatment. In conclusion, TCDD caused an adverse effect on rat's liver. When Q and CH were given together with TCDD, they prevented hepatotoxicty induced by TCDD. Thus, it is thought that Q and CH may be useful as a new category of anti-TCDD toxicity agent. (C) 2011 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipIUBAP (Scientific Research Fund of Inonu University) [2009/24]en_US
dc.description.sponsorshipContract grant sponsor: IUBAP (Scientific Research Fund of Inonu University); Contract grant number: 2009/24en_US
dc.identifier.doi10.1002/tox.20707
dc.identifier.endpage154en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue3en_US
dc.identifier.pmid21544919en_US
dc.identifier.scopus2-s2.0-84874218962en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://doi.org/10.1002/tox.20707
dc.identifier.urihttps://hdl.handle.net/11616/95966
dc.identifier.volume28en_US
dc.identifier.wosWOS:000318575400004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,3,7,8-TCDDen_US
dc.subjectquercetinen_US
dc.subjectchrysinen_US
dc.subjecthepatotoxicityen_US
dc.titleEffects of Quercetin and Chrysin on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induced Hepatotoxicity in Ratsen_US
dc.typeArticleen_US

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