Fast Curing Multifunctional Tissue Adhesives of Sericin-Based Polyurethane-Acrylates for Sternal Closure

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridKoytepe, Suleyman/0000-0002-4788-278X
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorNoma, Samir Abbas Ali
dc.contributor.authorUlu, Ahmet
dc.contributor.authorKaraaslan-Tunc, Merve Goksin
dc.contributor.authorOzhan, Onural
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2024-08-04T20:52:19Z
dc.date.available2024-08-04T20:52:19Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe use of wire cerclage after sternal closure is the standard method because of its rigidity and strength. Despite this, they have many disadvantages such as tissue trauma, operatorinduced failures, and the risk of infection. To avoid complications during sternotomy and promote tissue regeneration, tissue adhesives should be used in post-surgical treatment. Here, we report a highly biocompatible, biomimetic, biodegradable, antibacterial, and UV-curable polyurethane-acrylate (PU-A) tissue adhesive for sternal closure as a supportive to wire cerclage. In the study, PU-As were synthesized with variable biocompatible monomers, such as silk sericin, polyethylene glycol, dopamine, and an aliphatic isocyanate 4,4'-methylenebis(cyclohexyl isocyanate). The highest adhesion strength was found to be 4322 kPa, and the ex vivo compressive test result was determined as 715 kPa. The adhesive was determined to be highly biocompatible (on L929 cells), biodegradable, and antibacterial (on Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus bacteria). Finally, after opening the sternum of rats, the adhesive was applied to bond the bones and cured with UV for 5 min. According to the results, there was no visible inflammation in the adhesive groups, while some animals had high inflammation in the cyanoacrylate and wire cerclage groups. These results indicate that the adhesive may be suitable for sternal fixation by preventing the disadvantages of the steel wires and promoting tissue healing.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [116Z501]; Inonu University Research Fund [IUBAP FDP-2018-1284]en_US
dc.description.sponsorship? ACKNOWLEDGMENTS This work was supported financially by the Scientific and Technological Research Council of Turkey (Project no. 116Z501) and Inonu University Research Fund (IUBAP FDP-2018-1284) . The authors acknowledge Prof. Dr. Mehmet Fethi CEYLAN for his assistance in sternal closure surgery.en_US
dc.identifier.doi10.1021/acsami.2c14078
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.pmid36066351en_US
dc.identifier.scopus2-s2.0-85138068459en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1021/acsami.2c14078
dc.identifier.urihttps://hdl.handle.net/11616/100889
dc.identifier.wosWOS:000853675500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Applied Materials & Interfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbioadhesivesen_US
dc.subjectUV-curableen_US
dc.subjectpolyurethane-acrylateen_US
dc.subjectsternal closureen_US
dc.subjectsericinen_US
dc.titleFast Curing Multifunctional Tissue Adhesives of Sericin-Based Polyurethane-Acrylates for Sternal Closureen_US
dc.typeArticleen_US

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