HPLC method development for the simultaneous analysis of amlodipine and valsartan in combined dosage forms and in vitro dissolution studies

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dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.contributor.authorCelebier, Mustafa
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorAltinoz, Sacide
dc.contributor.authorSahin, Selma
dc.date.accessioned2024-08-04T20:32:50Z
dc.date.available2024-08-04T20:32:50Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA simple, rapid and reproducible HPLC method was developed for the simultaneous determination of amlodipine and valsartan in their combined dosage forms, and for drug dissolution studies. A C 18 column (ODS 2, 10 mu m, 200 x 4.6 mm) and a mobile phase of phosphate buffer (pH 3.6, 0.01 mol L-1): acetonitrile: methanol (46: 44: 10 v/v/v) mixture were used for separation and quantification. Analyses were run at a flow-rate of 1 mL min(-1) and at ambient temperature. The injection volume was 20 mu L and the ultraviolet detector was set at 240 nm. Under these conditions, amlodipine and valsartan were eluted at 7.1 min and 3.4 min, respectively. Total run time was shorter than 9 min. The developed method was validated according to the literature and found to be linear within the range 0.1 -50 mu g mL(-1) for amlodipine, and 0.05 - 50 mu g mL(-1) for valsartan. The developed method was applied successfully for quality control assay of amlodipine and valsartan in their combination drug product and in vitro dissolution studies.en_US
dc.identifier.doi10.1590/S1984-82502010000400018
dc.identifier.endpage768en_US
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-79956336483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage761en_US
dc.identifier.urihttps://doi.org/10.1590/S1984-82502010000400018
dc.identifier.urihttps://hdl.handle.net/11616/95329
dc.identifier.volume46en_US
dc.identifier.wosWOS:000208891500018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmlodipine besylateen_US
dc.subjectValsartanen_US
dc.subjectHigh Performance Liquid Chromatographyen_US
dc.subjectMethod Developmenten_US
dc.subjectValidationen_US
dc.subjectDissolution Studyen_US
dc.titleHPLC method development for the simultaneous analysis of amlodipine and valsartan in combined dosage forms and in vitro dissolution studiesen_US
dc.typeArticleen_US

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