SARS-COV-2 (COVID-19): Cellular and biochemical properties and pharmacological insights into new therapeutic developments

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridGunata, Mehmet/0000-0001-6905-4259
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidGunata, Mehmet/AAW-2738-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorGunata, Mehmet
dc.date.accessioned2024-08-04T20:48:57Z
dc.date.available2024-08-04T20:48:57Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCOVID-19 caused by SARS-COV-2 first appeared in the Wuhan City of China and began to spread rapidly among people. Rapid progression of the outbreak has led to a major global public health problem of a potentially fatal disease. On January 30, 2020, WHO declared the pandemic as the sixth public health emergency of the world. Upon this, the whole country has started to take the necessary precautions. The new coronavirus uses membrane-bound angiotensin-converting enzyme 2 (ACE2) to enter into the cells, such as SARS-CoV, and mostly affects the respiratory tract. Symptoms of COVID-19 patients include fever (93%), fatigue (70%), cough (70%), anorexia (40%) and dyspnoea (34.5%). The elderly and people with underlying chronic diseases are more susceptible to infection and higher mortality. Currently, a large number of drugs and vaccines studies are ongoing. In this review, we discussed the virology, epidemiological data, the replication of the virus, and its relationship with cardiovascular diseases on COVID-19 pandemics, treatment and vaccines. Thereby, this study aims to neatly present scientific data in light of many regarding literature that can be a clue for readers who research this disease prevention and treatment. Significance of the study This review summarized current information on COVID-19 (epidemiology, pathophysiology, clinical, laboratory, cardiovascular diseases, ACE2 and pharmacological agents) for researchers and reveals guiding data for researchers, especially in the field of cardiovascular system, pharmacology, dysregulation of cellular function in disease, molecular and cell biology and physiology in the regulation of tissue function in health and disease.en_US
dc.identifier.doi10.1002/cbf.3591
dc.identifier.endpage28en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue1en_US
dc.identifier.pmid32992409en_US
dc.identifier.scopus2-s2.0-85091689034en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.3591
dc.identifier.urihttps://hdl.handle.net/11616/99559
dc.identifier.volume39en_US
dc.identifier.wosWOS:000573371600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectACE2en_US
dc.subjectcardiovascular diseaseen_US
dc.subjectCOVID-19en_US
dc.subjectpandemiaen_US
dc.subjectpharmacological agentsen_US
dc.subjectvaccineen_US
dc.titleSARS-COV-2 (COVID-19): Cellular and biochemical properties and pharmacological insights into new therapeutic developmentsen_US
dc.typeReview Articleen_US

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