Effects of caffeic acid phenethyl ester on pancreatitis in rats

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoriderdogan, selim/0000-0002-9169-9771
dc.authoridVANIZOR KURAL, Birgul/0000-0003-0730-9660
dc.authorwosidKAKLIKKAYA, NESE/AAL-9100-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidTurkyilmaz, Serdar/AAL-8606-2021
dc.authorwosiderdogan, selim/AAT-2487-2020
dc.contributor.authorTurkyilmaz, Serdar
dc.contributor.authorAlhan, Etem
dc.contributor.authorErcin, Cengiz
dc.contributor.authorVanizor, Birgul Kural
dc.contributor.authorKaklikkaya, Nese
dc.contributor.authorAtes, Burhan
dc.contributor.authorErdogan, Selim
dc.date.accessioned2024-08-04T20:30:40Z
dc.date.available2024-08-04T20:30:40Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. This study investigated the effect of caffeic acid phenethyl ester (CAPE) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. CAPE, an active component of honeybee propolis, has previously been determined to have antioxidant, anti-inflammatory, antiviral, and anticancer activities. Materials and methods. Forty-eight rats were divided into four groups of 12. Group 1 animals received intraductal saline and intravenous saline infusion treatment. Group 2 was given intraductal saline and intraperitoneal CAPE infusion treatment. ANP was induced in the animals in group 3 (ANP with saline infusion), and group 4 had induced ANP plus CAPE infusion treatment (ANP with CAPE infusion). Sampling was performed 48 h after treatment. Results. ANP induction significantly increased mortality rate, pancreatic necrosis, and bacterial infection in pancreatic and extrapancreatic organs. ANP also increased levels of amylase and alanine aminotransferase (ALT) in serum, increased levels of urea and lactate dehydrogenase in bronchoalveolar lavage fluid (BAL LDH), increased the activities of myeloperoxidase (MPO) and malondialdehyde (AIDA) in pancreas and lung tissue, and decreased the serum calcium levels. The use of CAPE did not significantly reduce the mortality rate but significantly reduced the ALT and BAL LDH levels, the activities of MPO and MDA in the pancreas, the activity of MDA in the lungs, and pancreatic damage. The administration of CAPE did not reduce the bacterial infection. Conclusions. These results indicate that CAPE had beneficial effects on the course of ANP in rats and suggest that CAPE shows promise as a treatment for ANP. (c) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2007.04.019
dc.identifier.endpage24en_US
dc.identifier.issn0022-4804
dc.identifier.issue1en_US
dc.identifier.pmid18028950en_US
dc.identifier.scopus2-s2.0-38949083873en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2007.04.019
dc.identifier.urihttps://hdl.handle.net/11616/94450
dc.identifier.volume145en_US
dc.identifier.wosWOS:000253320800004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute necrotizing pancreatitisen_US
dc.subjectCAPEen_US
dc.subjectratsen_US
dc.titleEffects of caffeic acid phenethyl ester on pancreatitis in ratsen_US
dc.typeArticleen_US

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