Protective efficacy of Nigella sativa oil against the harmful effects of formaldehyde on rat testicular tissue

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridKose, Evren/0000-0002-0246-2589
dc.authoridCUGLAN, SONGUL/0000-0003-3572-1425
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidÇUĞLAN, Songül/AAP-8286-2021
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidÇUĞLAN, Songül/AAB-5025-2020
dc.contributor.authorSapmaz, Hilal Irmak
dc.contributor.authorYildiz, Azibe
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.contributor.authorKose, Evren
dc.contributor.authorTanbek, Keyser
dc.contributor.authorCuglan, Songul
dc.date.accessioned2024-08-04T20:45:35Z
dc.date.available2024-08-04T20:45:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To explore the effects of Nigella sativa oil (NSO) on the histopathological and biochemical changes that inhaled formaldehyde (FA) induces on the testicular tissue of rats. Methods: Thirty three adult male rats were separated into five groups as follows: C, the control group; 4FA group which received FA for 4 weeks; 13FA group which was given FA for 13 weeks; 4FA+NSO group which was administered FA plus NSO for 4 weeks; 13FA+NSO group which was treated with FA plus NSO for 13 weeks. FA was administered through inhalation for 8 h 5 days a week at a dose of 5 ppm in a special glass cage, and NSO was administered orally 1 mL/kg once daily. Rats were decapitated at the end of the experiment and testicular tissue specimens were harvested for histopathologic and biochemical assessment. Results: Compared to the C group, reduction was observed in the number of intact tubules and in the mean germinative epithelium thickness of the FA groups. Significant increase was observed in the number of intact tubules with the long-term (13 weeks) administration of NSO together with FA. Reduced glutathione peroxidase activity was found and oxidative stress index values were measured higher in the 4FA and 13FA groups versus the C group (P<0.05). Moreover, total antioxidant status levels decreased only in the 4FA group (P<0.05) while only the 13FA group significantly increased malondialdehyde levels and reduced catalase activities in comparison with the C group. In the 13FA+NSO group, malondialdehyde levels decreased however glutathione peroxidase and catalase activities increased compared to the 13FA group. Differences measured in total antioxidant status levels were found to be statistically significant only between the 4FA and the 4FA+NSO groups. Conclusions: NSO as an antioxidant should be used for a longer term to achieve protective efficacy both histoparhologically and biochemically in the testicular tissue.en_US
dc.identifier.doi10.4103/2221-1691.245970
dc.identifier.endpage553en_US
dc.identifier.issn2221-1691
dc.identifier.issn2588-9222
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85058375159en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage548en_US
dc.identifier.urihttps://doi.org/10.4103/2221-1691.245970
dc.identifier.urihttps://hdl.handle.net/11616/98572
dc.identifier.volume8en_US
dc.identifier.wosWOS:000452431300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectReproductive Toxicityen_US
dc.subjectOxidative Stressen_US
dc.subjectDamageen_US
dc.subjectInjuryen_US
dc.subjectModelen_US
dc.subjectAciden_US
dc.titleProtective efficacy of Nigella sativa oil against the harmful effects of formaldehyde on rat testicular tissueen_US
dc.typeArticleen_US

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