Melatonin protects against myocardial doxorubicin toxicity in rats: role of physiological concentrations

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorSahna, E
dc.contributor.authorParlakpinar, H
dc.contributor.authorOzer, MK
dc.contributor.authorOzturk, F
dc.contributor.authorOzugurlu, F
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:13:29Z
dc.date.available2024-08-04T20:13:29Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDoxorubicin (Dox) is a widely used antineoplastic drug. Oxygen radical-induced injury of membrane lipids is considered to be the most important factor responsible for the development of Dox-induced cardiotoxicity. The pineal secretory product, melatonin, is known to be a potent free radical scavenger and its pharmacological concentrations have been shown to reduce Dox-induced cardiac damage. However, the physiological role of melatonin in the prevention of this damage is unknown. We investigated physiological and pharmacological effects of melatonin on Dox-induced changes in the levels of malondialdehyde (MDA), a lipid peroxidation product, and morphological changes in heart. Rats were pinealectomized (Px) or sham-operated ( control) 2 months before the studies. Melatonin was administered [ 4 mg/kg, intraperitoneally (i.p.)] 1 hr before or 24 hr after the administration of a single dose of Dox ( 20 mg/kg, i.p.) and continued for 2 days. The levels of MDA Dox was found to be significantly higher in the Px rats (55.9 +/- 0.6 nmol/g tissue) than intact control animals (42.6 +/- 0.4). Dox administration to Px and non-Px rats significantly increased the MDA levels. Pre- and post-treatment with melatonin in both Px and intact rats significantly reduced MDA levels. Morphological changes parallelled the MDA alterations. These findings strongly suggest that both physiological and pharmacological concentrations of melatonin are important in protecting the heart from Dox-induced damage in rats. It would seem valuable to test melatonin in clinical trials for prevention of possible heart damage associated with Dox.en_US
dc.identifier.doi10.1034/j.1600-079X.2003.00084.x
dc.identifier.endpage261en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue4en_US
dc.identifier.pmid14521631en_US
dc.identifier.scopus2-s2.0-0242333263en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1034/j.1600-079X.2003.00084.x
dc.identifier.urihttps://hdl.handle.net/11616/93648
dc.identifier.volume35en_US
dc.identifier.wosWOS:000185679800006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdoxorubicinen_US
dc.subjecthearten_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectratsen_US
dc.titleMelatonin protects against myocardial doxorubicin toxicity in rats: role of physiological concentrationsen_US
dc.typeArticleen_US

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