Radioprotective effect of thymoquinone on salivary gland of rats exposed to total cranial irradiation

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dc.authoridAkyuz, Mehmet/0000-0001-7971-8389
dc.authoridAkyuz, Mehmet/0000-0001-7971-8389
dc.authoridTAYSI, Seyithan/0000-0003-1251-3148
dc.authorwosidAkyuz, Mehmet/JAC-7789-2023
dc.authorwosidAkyuz, Mehmet/R-5526-2019
dc.authorwosidbaysal, elif/AAH-6406-2019
dc.authorwosidDemir, Elif/ABG-2151-2020
dc.authorwosidTAYSI, Seyithan/G-6398-2019
dc.contributor.authorAkyuz, Mehmet
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorBaysal, Elif
dc.contributor.authorDemir, Elif
dc.contributor.authorAlkis, Hilal
dc.contributor.authorAkan, Muslum
dc.contributor.authorBinici, Habip
dc.date.accessioned2024-08-04T20:43:15Z
dc.date.available2024-08-04T20:43:15Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The purpose of this study was to investigate the radioprotective effects of thymoquinone against radiation-induced damage in the salivary glands of rats exposed to total cranial gamma irradiation. Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups to test the radioprotective effectiveness of thymoquinone by intraperitoneal injection. An appropriate control group was also studied. Biochemical parameters in liver tissue of rats were determined by spectrophotometer. Results: Glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), total (enzymatic plus nonenzymatic) superoxide scavenger activity (TSSA), nonenzymatic superoxide scavenger activity (NSSA), and superoxide dismutase (SOD) activities were significantly decreased, whereas xanthine oxidase, nitric oxide synthase activities, malondialdehyde, nitric oxide, and peroxynitrite levels were significantly increased in the irradiation group when compared to the control and sham control groups. Conclusion: Results showed that thymoquinone reduces oxidative and nitrosative stress parameters and has antioxidant effects and a free radical scavenging activity.en_US
dc.identifier.doi10.1002/hed.24861
dc.identifier.endpage2035en_US
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.issue10en_US
dc.identifier.pmid28708300en_US
dc.identifier.scopus2-s2.0-85023610937en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2027en_US
dc.identifier.urihttps://doi.org/10.1002/hed.24861
dc.identifier.urihttps://hdl.handle.net/11616/97889
dc.identifier.volume39en_US
dc.identifier.wosWOS:000410553500013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHead and Neck-Journal For The Sciences and Specialties of The Head and Necken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidant enzymesen_US
dc.subjectirradiationen_US
dc.subjectoxidative stressen_US
dc.subjectsalivary glanden_US
dc.subjectthymoquinoneen_US
dc.titleRadioprotective effect of thymoquinone on salivary gland of rats exposed to total cranial irradiationen_US
dc.typeArticleen_US

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