Determination of trace elements in kidneys, livers and brains of rats with sealer implants by ICP-MS

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dc.authoridsimsek, neslihan/0000-0003-1142-9016
dc.authorwosidAKINCI, Levent/W-3128-2017
dc.authorwosidalan, hilal/ABH-9301-2020
dc.authorwosidsimsek, neslihan/ABF-1071-2020
dc.contributor.authorSimsek, Neslihan
dc.contributor.authorAkinci, Levent
dc.contributor.authorAlan, Hilal
dc.contributor.authorGecor, Orhan
dc.contributor.authorOzan, Ulku
dc.date.accessioned2024-08-04T20:42:56Z
dc.date.available2024-08-04T20:42:56Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFollowing root canal treatment, sealers may contact periapical tissue. The purpose of this study was to evaluate the systemic toxic effects of epoxy resin-based sealers (AH Plus and Obtuseal). Inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure levels of trace elements (beryllium, magnesium, aluminium, calcium, chromium, arsenic and lead) in the brain, kidney and liver of rats. Twenty sterilized polyethylene tubes were then filled with AH Plus and Obtuseal and implanted into the dorsal subcutaneous tissue of 10 rats; three unoperated animals were used as a control group. After 45 days, the rats were sacrificed by cervical dislocation following anaesthesia, and brains, kidneys and livers were removed from all experimental animals. ICP-MS analysis was used to determine levels of trace elements. Data were analysed using Kruskal-Wallis and Connover post hoc tests. No significant differences were found in aluminium and calcium levels, but brains, kidneys and livers showed significantly higher amounts of magnesium and chromium than the corresponding controls. In the kidney and liver samples, arsenic levels were found to be higher than in the control group. Lead was detected at higher levels only in liver samples from the AH Plus group. Beryllium was not detected in any organ. It was concluded that AH Plus and Obtuseal release minimal quantities of trace elements when in contact with subcutaneous tissue, and further studies are needed to understand the systemic effects of these materials.en_US
dc.description.sponsorshipInonu University/Turkey, Scientific Research Projects Unit [2013/117]en_US
dc.description.sponsorshipThis project was supported by Inonu University/Turkey, Scientific Research Projects Unit [grant number 2013/117].en_US
dc.identifier.doi10.1080/13102818.2017.1282327
dc.identifier.endpage402en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85011890533en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2017.1282327
dc.identifier.urihttps://hdl.handle.net/11616/97684
dc.identifier.volume31en_US
dc.identifier.wosWOS:000399341000024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndodonticsen_US
dc.subjectepoxy resin-based sealersen_US
dc.subjectICP-MSen_US
dc.subjecttrace elementsen_US
dc.titleDetermination of trace elements in kidneys, livers and brains of rats with sealer implants by ICP-MSen_US
dc.typeArticleen_US

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