The Histopathologic Effects of L-Carnitine in a Sodium Taurocholate-Induced Severe Pancreatitis Model

Basit Öğe Kaydı
dc.contributor.authorKarakahya, Murat
dc.contributor.authorGul, Mehmet
dc.contributor.authorIslk, Sevil
dc.contributor.authorAydin, Cemalettin
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorOtan, Emrah
dc.contributor.authorTaner, Orug
dc.date.accessioned2024-08-04T20:43:02Z
dc.date.available2024-08-04T20:43:02Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aims to evaluate the histopathologic effects of L-carnitine (LC) in an experimental severe pancreatitis (SP) model induced with sodium taurocholate. LC is an amino acid-like molecule that plays an active role in transporting fatty acids and producing acetyl CoA in mitochondrial matrix for beta-oxidation to provide energy that is needed for metabolism. It has ameliorative effects on cell injury, as has been demonstrated in many studies. The present study focuses on evaluating the histopathologic effects of LC in an experimental SP model. A total of 32 Sprague-Dawley male rats were divided into 4 groups in a randomized fashion: control (C) group, L-carnitine (LC) group, pancreatitis (P) group, and pancreatitis and L-carnitine (P + LC) group. Pancreatitis was induced by a retrograde pancreatic duct injection of 4% sodium taurocholate, and LC was administered 200 mg/kg/d in the treatment group. Rats were euthanized with cardiac puncture under anesthesia at the 48th hour of the experiment for biochemical and histopathologic examination. In the P + LC group, the histopathologic findings of the pancreatitis were markedly reduced. Acinar cell degeneration was rarely seen. Interlobular and intralobular inflammation and edema was generally mild. The pancreatic damage score of the P + LC group was significantly lower than that of the P group (P < 0.05). This study revealed that LC has a significant histopathologic protective effect on acinar cell degeneration in a sodium taurocholate-induced SP model in rats.en_US
dc.identifier.doi10.9738/INTSURG-D-16-00058.1
dc.identifier.endpage248en_US
dc.identifier.issn0020-8868
dc.identifier.issue5-6en_US
dc.identifier.scopus2-s2.0-85015869058en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-16-00058.1
dc.identifier.urihttps://hdl.handle.net/11616/97746
dc.identifier.volume101en_US
dc.identifier.wosWOS:000402283400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInt College Of Surgeonsen_US
dc.relation.ispartofInternational Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectL-carnitineen_US
dc.subjectSodium taurocholateen_US
dc.subjectSevere pancreatitisen_US
dc.titleThe Histopathologic Effects of L-Carnitine in a Sodium Taurocholate-Induced Severe Pancreatitis Modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu