Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses

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dc.authoridULUSOY, HALIL IBRAHIM/0000-0002-8742-5145
dc.authoridUğur, Yılmaz/0000-0002-9040-4249
dc.authoridOzgur, Mustafa Erkan/0000-0002-2966-9627
dc.authorwosidULUSOY, HALIL IBRAHIM/A-3777-2013
dc.authorwosidUğur, Yılmaz/ABI-4076-2020
dc.authorwosidUğur, Yılmaz/AAA-4699-2022
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorMaras, Zeynep
dc.contributor.authorOzgur, Mustafa Erkan
dc.contributor.authorDurmaz, Murat
dc.contributor.authorUlusoy, Halil Ibrahim
dc.contributor.authorErdogan, Selim
dc.contributor.authorUgur, Yilmaz
dc.date.accessioned2024-08-04T20:50:35Z
dc.date.available2024-08-04T20:50:35Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMetamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methylamino antipyrine (MAA), an active primary metabolite of MT. The present study aims to determine the pharmacokinetic (PK) profiles of MT metabolites after intravenous (IV) and intramuscular (IM) administration into sex of Arabian horses (Equus ferus caballus) using a cross-over study design. The plasma samples were extracted by solid-phase extraction (SPE) method, and plasma concentrations of MT metabolites were analyzed by high-performance liquid chromatography (HPLC). After administrations of MT, plasma concentrations of methylamino antipyrine (MAA), amino antipyrone (AA), and acetylamino antipyrone (AAA) were determined within range of 15 min-12 h. Plasma concentrations of AA and AAA were lower than the plasma concentrations of major metabolite MAA at each sampling point. The PK parameters were statistically evaluated for MT's metabolites between male and female horses and also between IM and IV administrations of PK parameters such as C-max, t(max), t(1/2 lambda z), AUC(0-t), AUC(0-infinity), lambda z, Cl and V-ss (p < .05). The AUC(IM)/AUC(IV) ratio in female and male horses for MAA was 1.19 and 1.13, respectively. The AUC(IM)/AUC(IV) ratio for AA was lower than those found for MAA. AUC(IM)/AUC(IV) ratio was statistically significantly different between male and female horses for AA (p < .05). According to these results, some PK parameters such as Cmax, AUC, and MRT, MAA and AA concentrations have shown statistically significant differences by MT administrations.en_US
dc.description.sponsorshipInonu University Scientific Research Fund [2018/1044]; Inonu University Scientific Research Projects Uniten_US
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Fund (Project number: 2018/1044). We would like to thank the Inonu University Scientific Research Projects Unit for the financial support.en_US
dc.identifier.doi10.1111/jvp.13003
dc.identifier.endpage936en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue6en_US
dc.identifier.pmid34431528en_US
dc.identifier.scopus2-s2.0-85113349552en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage927en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.13003
dc.identifier.urihttps://hdl.handle.net/11616/100157
dc.identifier.volume44en_US
dc.identifier.wosWOS:000688081600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArabian horsesen_US
dc.subjectHPLCen_US
dc.subjectMetamizoleen_US
dc.subjectpharmacokineticsen_US
dc.subjectsolid-phase extractionen_US
dc.titlePharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horsesen_US
dc.typeArticleen_US

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