Synthesis and evaluation of anticancer properties of novel benzimidazole ligand and their cobalt(II) and zinc(II) complexes against cancer cell lines A-2780 and DU-145

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dc.authoridYılmaz, Ülkü/0000-0002-2806-4781
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridBugday, Nesrin/0000-0002-3882-035X
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidYılmaz, Ülkü/AAA-7545-2020
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.contributor.authorYilmaz, Ulku
dc.contributor.authorTekin, Suat
dc.contributor.authorBugday, Nesrin
dc.contributor.authorYavuz, Kemal
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:46:01Z
dc.date.available2024-08-04T20:46:01Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEighteen new cobalt(II) or zinc(II) complexes of benzimidazole bearing 1-benzyl and 2-phenyl moieties were synthesized from the reaction of appropriate benzimidazole ligands and CoCl2 or ZnCl2. Their structural characterizations were done by IR, NMR (H-1, C-13) and UV-VIS spectrometers. Cytotoxic activities of eighteen new complexes and three benzimidazole ligands were determined using A-2780 (human ovarian) and DU-145 (human prostate) cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested benzimidazole derivatives was performed and the LogIC(50) values of the compounds were calculated after a 24-hour treatment. All tested benzimidazole derivatives showed higher or comparable antitumor activity against A-2780 cell lines compared to the standard drug docetaxel with a LogIC(50) value of -0.81 mu M (p < 0.05). Eight of the examined compounds (1, 3, 5, 6, 7, 9, 10 and 13) showed high cytotoxic activity against A-2780 compared to the standard drug docetaxel. While the LogIC(50) of the docetaxel was -0.81 mu M for A-2780 cells at 24 h, the IC50 values of compounds 1, 3, 5, 6, 7, 9, 10 and 13 were - 0.97, -1.30, - 0.22, 0.13, - 0.16, - 0.73 and - 0.53 mu M, respectively. Three of the compounds 1, 18 and V showed high cytotoxic activity against DU-145 compared to docetaxel (p < 0.05). While the LogIC(50) of the docetaxel was -1.13 mu M for DU-145 cells at 24 h, the LogIC(50) values of compounds 1, 18 and V were 0.84, -0.38 and -0.66 mu M, respectively.en_US
dc.description.sponsorshipInonu University, Turkey [2014/33]en_US
dc.description.sponsorshipWe thank Inonu University, Turkey (BAPB-Grand No: 2014/33) for financial support.en_US
dc.identifier.doi10.1016/j.ica.2019.118977
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85067980264en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2019.118977
dc.identifier.urihttps://hdl.handle.net/11616/98844
dc.identifier.volume495en_US
dc.identifier.wosWOS:000481728800045en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazole complexesen_US
dc.subjectCytotoxicen_US
dc.subjectA-2780 cell linesen_US
dc.subjectDU-145 cell linesen_US
dc.titleSynthesis and evaluation of anticancer properties of novel benzimidazole ligand and their cobalt(II) and zinc(II) complexes against cancer cell lines A-2780 and DU-145en_US
dc.typeArticleen_US

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