Micro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvarium

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridYolcu, Ümit/0000-0001-7312-2867
dc.authoridKeleş, Ali/0000-0003-2835-767X
dc.authoridkahraman, sevil/0000-0003-3573-1068
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidYolcu, Ümit/ABH-6916-2020
dc.authorwosidKeleş, Ali/J-5897-2015
dc.authorwosidkahraman, sevil/HKE-3001-2023
dc.contributor.authorAcar, Ahmet Huseyin
dc.contributor.authorYolcu, Umit
dc.contributor.authorGul, Mehmet
dc.contributor.authorKeles, Ali
dc.contributor.authorErdem, Necip Fazil
dc.contributor.authorKahraman, Sevil Altundag
dc.date.accessioned2024-08-04T20:40:08Z
dc.date.available2024-08-04T20:40:08Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (beta TCP). Design: In this study, 20 New Zealand white rabbits were used and four calvarial defects were prepared in each animal. PEP, Straumann (R) Bone Ceramic (SBC), or PEP + SBC was applied to the defects; one defect was left untreated as a control. Ten rabbits were sacrificed at week 4(T-1) and 10 at week 8 (T-2). After micro-computed tomography (micro-CT) scanning, the samples were sent for histological and histomorphometric analysis to evaluate and compare the volume and area of regenerated bone. Results: Histomorphometric and micro-CT analysis showed that both PEP and SBC significantly increased bone regeneration at T-1 and T-2 (P < 0.01). When PEP was used in combination with HA/beta TCP, a further significant increase in new bone formation was observed at T-1 and T-2 compared with that when PRF or SBC was used alone (P < 0.01). Conclusions: PRF has a positive effect on bone formation when used alone and in combination with HA/beta TCP. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University [2013-128]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Inonu University under project number 2013-128.en_US
dc.identifier.doi10.1016/j.archoralbio.2014.09.017
dc.identifier.endpage614en_US
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.issue4en_US
dc.identifier.pmid25621939en_US
dc.identifier.scopus2-s2.0-84925610565en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage606en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2014.09.017
dc.identifier.urihttps://hdl.handle.net/11616/96725
dc.identifier.volume60en_US
dc.identifier.wosWOS:000351790000012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlatelet-rich fibrinen_US
dc.subjectRabbiten_US
dc.subjectCalvarial defecten_US
dc.subjectHydroxyapatiteen_US
dc.subjectBeta-tricalcium phosphateen_US
dc.titleMicro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvariumen_US
dc.typeArticleen_US

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