Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-?B and bcl-2/bax pathway

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dc.authoridBeyaz, Seda/0000-0003-0436-8112
dc.authoridBEYAZ, SEDA/0000-0003-0436-8112
dc.authoridParlak, Gozde/0000-0002-8982-887X
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridGök, Özlem/0000-0001-8521-6369
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridCan, Muhammed Ismail/0000-0002-0118-2278
dc.authorwosidBeyaz, Seda/ABD-1252-2021
dc.authorwosidBEYAZ, SEDA/ABI-5835-2020
dc.authorwosidParlak, Gozde/ISA-6808-2023
dc.authorwosidCan, Muhammed İsmail/ABG-8646-2020
dc.authorwosidcan, mi/KDN-4165-2024
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidGök, Özlem/AFV-8223-2022
dc.contributor.authorAslan, Abdullah
dc.contributor.authorBeyaz, Seda
dc.contributor.authorGok, Ozlem
dc.contributor.authorCan, Muhammed Ismail
dc.contributor.authorParlak, Gozde
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorGundogdu, Ramazan
dc.date.accessioned2024-08-04T20:50:33Z
dc.date.available2024-08-04T20:50:33Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRoyal jelly is known to strengthen memory, provide antioxidative, antidiabetic, antitumor, anticancer, antibacterial, antiinflammatory, antihypertensive. In this study, 42 rats (n = 42) were used, and these rats were divided into 6 groups of 7 rats each. Groups: (i) Control Group: Group fed with standard diet; (ii) Royal Jelly (RJ) Group: RJ (100 mg/kg bw, gavage); (iii) F50 Group: Fluoride (50 mg/kg bw, drinking water); (iv) F100 Group: F (100 mg/kg bw, drinking water); (v) F50 + RJ Group: F (50 mg/kg bw, drinking water) + RJ (100 mg/kg bw, gavage); (vi) F100 + RJ Group: F (100 mg/kg bw, drinking water) + RJ (100 mg/kg bw, gavage). The rats were decapitated after 8 weeks, and their heart tissues were taken and examined. Lipid peroxidation by MDA (malondialdehyde) analyzes, GSH (glutathione) level and catalase activity were determined by spectrophotometer. Protein expression levels of caspase-3, caspase-6, caspase-9, Bcl-2, Bax, BDNF, Gsk-3, Nrf-2 and NF-kappa B proteins in heart tissue were determined by western blotting technique and hearth tissue evaluated by histopathologically. As a result, MDA levels, Bcl-2, Gsk-3 and NF-kappa B protein expression levels were reduced, whereas GSH levels, caspase-3, caspase-9, caspase-6, Bax, BDNF and Nrf-2 protein levels were increased in the F50 + RJ and F100 + RJ groups compared to the F50 and F100 groups. According to the results of this study, it has been concluded that Royal jelly has the potential to be developed in to a drug for treatment of heart diseases in addition to providing protection against heart damage.en_US
dc.description.sponsorshipFirat University Research Projects Unit (FUBAP) [FF.19.16]en_US
dc.description.sponsorshipThis work was supported by Firat University Research Projects Unit (FUBAP) [Grant No. FF.19.16].en_US
dc.identifier.doi10.1080/15376516.2021.1950249
dc.identifier.endpage654en_US
dc.identifier.issn1537-6516
dc.identifier.issn1537-6524
dc.identifier.issue9en_US
dc.identifier.pmid34227456en_US
dc.identifier.scopus2-s2.0-85112750127en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage644en_US
dc.identifier.urihttps://doi.org/10.1080/15376516.2021.1950249
dc.identifier.urihttps://hdl.handle.net/11616/100138
dc.identifier.volume31en_US
dc.identifier.wosWOS:000685937100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofToxicology Mechanisms and Methodsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBaxen_US
dc.subjectGsk-3en_US
dc.subjectFluorideen_US
dc.subjectHeart tissue damageen_US
dc.subjectRoyal jellyen_US
dc.titleRoyal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-?B and bcl-2/bax pathwayen_US
dc.typeArticleen_US

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