Royal jelly protects brain tissue against fluoride-induced damage by activating Bcl-2/NF-?B/caspase-3/caspase-6/Bax and Erk signaling pathways in rats

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dc.authoridParlak, Gozde/0000-0002-8982-887X
dc.authoridGök, Özlem/0000-0001-8521-6369
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridPARLAK, AKIF EVREN/0000-0002-2579-9985
dc.authoridCan, Muhammed Ismail/0000-0002-0118-2278
dc.authorwosidParlak, Gozde/ISA-6808-2023
dc.authorwosidGök, Özlem/AFV-8223-2022
dc.authorwosidcan, mi/KDN-4165-2024
dc.authorwosidAslan, Abdullah/C-9523-2016
dc.authorwosidPARLAK, AKIF EVREN/V-8579-2018
dc.contributor.authorAslan, Abdullah
dc.contributor.authorBeyaz, Seda
dc.contributor.authorGok, Ozlem
dc.contributor.authorParlak, Gozde
dc.contributor.authorCan, Muhammed Ismail
dc.contributor.authorAgca, Can Ali
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.date.accessioned2024-08-04T20:53:25Z
dc.date.available2024-08-04T20:53:25Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study is aimed at determining whether royal jelly (RJ) which has a powerful antioxidant property prevents fluoride-induced brain tissue damage and exploring whether Bcl-2/NF-kappa B/ and caspase-3/caspase-6/Bax/Erk pathways play a critical role in the neuroprotective effect of RJ. Wistar albino rats were chosen for the study, and they were randomly distributed into six groups: (i) control; (ii) royal jelly; (iii) fluoride-50; (iv) fluoride-100; (v) fluoride-50 + royal jelly; (vi) fluoride-100 + royal jelly. We established fluoride-induced brain tissue damage with 8-week-old male Wistar albino rats by administration of fluoride exposure (either 50 mg/kg or 100 mg/kg bw) through drinking water for 8 weeks. Then, the study duration is for 56 days where the rats were treated with or without RJ (100 mg/kg bw) through oral gavage. The effects of RJ on glutathione (GSH), catalase activity (CAT), and malondialdehyde (MDA) levels were determined via spectrophotometer. Western blot analysis was performed to investigate the effects of royal jelly on the protein expression levels of Bax, caspase-3, caspase-6, Bcl-2, NF-kappa B, COX-2, and Erk. It was also studied the effects of RJ on histopathological alterations in fluoride-induced damage to the rat brain. As a result, the Bcl-2, NF-kappa B, and COX-2 protein expression levels were increased in the fluoride-treated (50 and 100 mg/kg) groups but they were decreased significantly by RJ treatment in the brain tissue. Additionally, the protein expression of caspase-3, caspase-6, Bax, and Erk were decreased in fluoride-treated groups and they were significantly increased by RJ treatment compared to the un-treated rats. Our results suggested that RJ prevented fluoride-induced brain tissue damage through anti-antioxidant activities.en_US
dc.description.sponsorshipFirat University Research Projects Unit (FUBAP) [FF.19.16]en_US
dc.description.sponsorshipFinancial support was provided from the Firat University Research Projects Unit (FUBAP) [Grant No. FF.19.16].en_US
dc.identifier.doi10.1007/s11356-023-25636-y
dc.identifier.endpage49025en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue17en_US
dc.identifier.pmid36759409en_US
dc.identifier.scopus2-s2.0-85147774844en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage49014en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-023-25636-y
dc.identifier.urihttps://hdl.handle.net/11616/101167
dc.identifier.volume30en_US
dc.identifier.wosWOS:000931997300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectBrain damageen_US
dc.subjectCaspase-3en_US
dc.subject6en_US
dc.subjectFluorideen_US
dc.subjectOxidative stressen_US
dc.subjectRoyal jellyen_US
dc.titleRoyal jelly protects brain tissue against fluoride-induced damage by activating Bcl-2/NF-?B/caspase-3/caspase-6/Bax and Erk signaling pathways in ratsen_US
dc.typeArticleen_US

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