The effect of melatonin on acetylsalicylic acid-induced kidney and testis damage

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridyoldas, zeynep rumeysa/0000-0002-5608-9003
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidaltintas, ramazan/AAP-2348-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorAltintas, R.
dc.contributor.authorPolat, A.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorVardi, N.
dc.contributor.authorBeytur, A.
dc.contributor.authorOguz, F.
dc.contributor.authorSagir, M.
dc.date.accessioned2024-08-04T20:39:39Z
dc.date.available2024-08-04T20:39:39Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the acute effect of high-dose acetylsalicylic acid (ASA) on kidney and testis, and the potential protective and therapeutic effects of melatonin on ASA-related pathology. A total of 40 rats were randomly divided into the following 5 groups (n = 8): group 1: control, not given any drug; group 2: only 200 mg/kg ASA was given; group 3: 5 mg/kg melatonin was given 45 min before administering 200 mg/kg ASA; group 4: 5 mg/kg melatonin was given 45 min after administering 200 mg/kg ASA; and group 5: only 5 mg/kg melatonin was given. The histopathological changes and the biochemical findings; such as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), and blood urea nitrogen (BUN) as well as serum creatinine (Cr) levels were evaluated. ASA significantly increased MDA levels in both kidney and testis, whereas it significantly decreased the values of SOD, CAT, GPX, and GSH in kidney and CAT levels in testis. Melatonin significantly decreased MDA levels in kidney and ameliorated it in testis, whereas it caused elevation in the levels of antioxidants. BUN and Cr levels were higher after ASA, whereas these levels were diminished after melatonin administration. The improvement obtained by melatonin on ASA-induced histological alterations was more prominent when it was used after ASA in kidney and before ASA in testis. In this study, we demonstrated the beneficial effect of melatonin on high-dose ASA-related pathology of kidney and testis for the first time.en_US
dc.identifier.doi10.1177/0960327113506240
dc.identifier.endpage395en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue4en_US
dc.identifier.pmid24107454en_US
dc.identifier.scopus2-s2.0-84897889444en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://doi.org/10.1177/0960327113506240
dc.identifier.urihttps://hdl.handle.net/11616/96403
dc.identifier.volume33en_US
dc.identifier.wosWOS:000332923800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttestisen_US
dc.subjectAcetylsalicylic aciden_US
dc.subjectmelatoninen_US
dc.subjectraten_US
dc.subjectkidneyen_US
dc.titleThe effect of melatonin on acetylsalicylic acid-induced kidney and testis damageen_US
dc.typeArticleen_US

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